{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:26:37Z","timestamp":1793571997408,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate intraoperative assessment and monitoring of liver tumor ablations using contrast-enhanced ultrasound (CEUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty patients (11 males [65%] and 9 females [45%]) with malignant lesions (cholangiocellular carcinoma (CCC), 1; hepatocellular carcinoma (HCC), 5; colorectal liver metastases (CRLM), 13; and one patient with alveolar echinococcosis) were examined intraoperatively with CEUS. Images were acquired in cine loops, covering the early arterial phase (0\u201315\u2005s) up to the portal venous phase (1\u2005min). Ablation was performed under real-time ultrasound guidance using microwave ablation (MWA). The generator output was adjusted up to 80\u2005watts, up to 10\u2005min. Post-ablation CEUS was conducted for immediate control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients underwent ablation procedures. Ablation was carried out under ultrasound guidance with adjusted output settings between 40 and 80\u2005watts and durations ranging from 2 to 5\u2005min. Post-interventional CEUS confirmed complete devascularization in all planes. All patients underwent track ablation using 70\u2005watts. At 6-month follow-up, no local recurrence was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preliminary findings demonstrate the feasibility of intraoperative CEUS during microwave ablation of liver lesions. The technique proves to be a safe and effective intraoperative tool, owing to its ability to provide verification of complete tumor devascularization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291261491824","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:03:42Z","timestamp":1790607822000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative monitoring of malignant liver tumor microwave ablation using contrast-enhanced ultrasound: A preliminary study"],"prefix":"10.1177","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-4964","authenticated-orcid":false,"given":"Ivor","family":"Dropco","sequence":"first","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"K\u00e4ser","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kaiser","sequence":"additional","affiliation":[{"name":"\u00dcBAG Dr. Vehling-Kaiser MVZ GmbH, Landshut, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kupke","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J\u00fcrgen","family":"Schlitt","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M","family":"Brunner","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hackl","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stroszczynski","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta17090"},{"key":"e_1_3_3_3_2","first-page":"319","article-title":"Intraoperative ultrasound in liver and pancreatic surgery","volume":"23","author":"Barto\u0219 A","year":"2021","unstructured":"Barto\u0219 A, Iancu I, Ciobanu L, et al. Intraoperative ultrasound in liver and pancreatic surgery. Med Ultrason 2021; 23: 319\u2013328.","journal-title":"Med Ultrason"},{"key":"e_1_3_3_4_2","article-title":"Contrast-enhanced ultrasound algorithms (CEUS-LIRADS\/ESCULAP) for the noninvasive diagnosis of hepatocellular carcinoma \u2013 A prospective multicenter DEGUM study","volume":"42","author":"Schellhaas B","year":"2021","unstructured":"Schellhaas B, Bernatik T, Bohle W, et al. Contrast-enhanced ultrasound algorithms (CEUS-LIRADS\/ESCULAP) for the noninvasive diagnosis of hepatocellular carcinoma \u2013 A prospective multicenter DEGUM study. Ultraschall Med 2021; 42: e20.","journal-title":"Ultraschall Med"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-179112"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2203-2733"},{"key":"e_1_3_3_7_2","first-page":"49","article-title":"Intraoperative contrast-enhanced ultrasound has an outcome-relevant impact on surgery of primary and metastatic liver lesions","volume":"46","author":"Bitterer F","year":"2024","unstructured":"Bitterer F, Bauer A, Glehr G, et al. Intraoperative contrast-enhanced ultrasound has an outcome-relevant impact on surgery of primary and metastatic liver lesions. Ultraschall Med 2024; 46: 49\u201356.","journal-title":"Ultraschall Med"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15545"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2157-2587"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1027806"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-0012-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02573-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11071244"},{"key":"e_1_3_3_14_2","first-page":"498","article-title":"Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins","volume":"298","author":"Dropco I","year":"2025","unstructured":"Dropco I, Kaiser U, Jung F, et al. Intraoperative contrast-enhanced ultrasound (CEUS) with time intensity curve (TIC) analysis for better assessment of liver tumor margins. Rofo 2025; 298: 498\u2013507.","journal-title":"Rofo"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-5589"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-018-0411-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2306-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1687945"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3448"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12044"},{"key":"e_1_3_3_22_2","first-page":"1199","article-title":"Contrast-enhanced intraoperative ultrasound shows excellent performance in improving intraoperative decision-making","volume":"14","author":"Kupke LS","year":"2024","unstructured":"Kupke LS, Dropco I, G\u00f6tz M, et al. Contrast-enhanced intraoperative ultrasound shows excellent performance in improving intraoperative decision-making. Life (Basel). 2024; 14: 1199.","journal-title":"Life (Basel)"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2010-1336"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-232055"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-200898"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-4997"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261491824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291261491824","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261491824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:39:59Z","timestamp":1793569199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291261491824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1177\/13860291261491824"],"URL":"https:\/\/doi.org\/10.1177\/13860291261491824","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}