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Important fact, oxidative stress participates in the AD development by promoting amyloid-\u03b2 deposition, tau hyperphosphorylation. However, the inflammatory response and pyroptotic death are mediated by the aberrant expression of NLRP inflammasome activated caspase-1, which leads to cleavage pro-inflammatory cytokines such as pro-interleukin-1\u03b2 and pro-IL-18. IL-1\u03b2, TNF-\u03b1, and IL-6 which amplify the neuroinflammation loop, are produce by activated microglia and astrocytes, that can serve as early diagnostic markers or therapeutic targets in AD. 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