{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:05Z","timestamp":1777396685749,"version":"3.51.4"},"reference-count":88,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression and circadian rhythm disruptions are non-cognitive neuropsychiatric symptoms (NPS) that can appear at any stage of the Alzheimer's disease (AD) continuum. Evidence suggests that NPS are linked to AD pathophysiology and hippocampal dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine structural white matter (WM) connectivity and its association with gray matter (GM) atrophy and to identify specific AD-related neural networks linked to NPS in individuals with mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety-six older adults participants were divided into three groups based on the Global Depression Scale, Neuropsychiatric Inventory, Clinical Dementia Rating, and Mini-Mental Status Examination. Twelve individuals with MCI and NPS (MCI+) and 49 without NPS (MCI-) were classified, along with 35 age and gender-matched healthy individuals. Voxel-based morphometry and tract-based spatial statistics were employed to identify structural and microstructural alterations. Network-based statistics analyzed structural WM connectivity differences between MCI groups and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant structural WM connectivity and GM loss were exclusively observed in MCI+ individuals compared to controls. The hippocampus, amygdala, and sensory cortex showed GM atrophy (p\u2009&lt;\u20090.05), while the thalamus, pallidum, putamen, caudate, hippocampus, and sensory and frontal cortices exhibited structural WM connectivity loss (p\u2009&lt;\u20090.01). These data indicate early limbic system involvement even without GM atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Structural WM connectivity loss within the Papez circuit may precede and potentially predict GM atrophy in the temporal lobe of individuals with MCI+. These findings highlight the importance of investigating structural WM alterations in the prodromal phase of AD, which may inform diagnostic and therapeutic strategies in early AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241288710","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:55:01Z","timestamp":1732499701000},"page":"1042-1056","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Structural white matter connectivity differences independent of gray matter loss in mild cognitive impairment with neuropsychiatric symptoms: Early indicators of Alzheimer's disease using network-based statistics"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-0727","authenticated-orcid":false,"given":"Amir Mohammad","family":"Pajavand","sequence":"first","affiliation":[{"name":"The National University of Iran (NUI), 19839-63113, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel J","family":"Grothe","sequence":"additional","affiliation":[{"name":"Reina Sofia Alzheimer Center, CIEN Foundation-ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Thiebaut","family":"De Schotten","sequence":"additional","affiliation":[{"name":"Brain Connectivity and Behaviour Laboratory, Sorbonne University, Paris, France"},{"name":"Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives-UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo Sean","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, Pisa, 56126, Italy"},{"name":"IRCCS Stella Maris Foundation, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vergallo","sequence":"additional","affiliation":[{"name":"Sorbonne University, Alzheimer Precision Medicine, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Boulevard de l'h\u00f4pital, F-75013, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-8982","authenticated-orcid":false,"given":"Harald","family":"Hampel","sequence":"additional","affiliation":[{"name":"Sorbonne University, Alzheimer Precision Medicine, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Boulevard de l'h\u00f4pital, F-75013, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"bibr1-13872877241288710","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.669490"},{"key":"bibr2-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.06.004"},{"key":"bibr3-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83585-3"},{"key":"bibr4-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"bibr5-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4521-10.2010"},{"key":"bibr6-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"bibr7-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"bibr8-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01279-6"},{"key":"bibr9-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-019-1058-4"},{"key":"bibr10-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5244"},{"key":"bibr11-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110010"},{"key":"bibr12-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74314-3"},{"key":"bibr13-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0694-0"},{"key":"bibr14-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9767-y"},{"key":"bibr15-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.009"},{"key":"bibr16-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-016-1319-z"},{"key":"bibr17-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00869-6"},{"key":"bibr18-13872877241288710","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.01.012"},{"key":"bibr19-13872877241288710","unstructured":"Johansson M. 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