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Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Framingham Heart Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum adiponectin, retinol-binding protein 4 (RBP4), fetuin-A, and Fatty Acid-Binding Protein 4 (FABP4) concentrations were measured by enzymatic immunoassays. MRI measures included total brain, cortical gray matter, hippocampal (total and anterior), lateral ventricular, and white matter hyperintensity volumes. We used linear regression models to separately relate adipokine concentrations to MRI measures, adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1882 participants (mean age of 48\u2009\u00b1\u20098 years, 54% women). Higher RBP4 concentrations were related to markers of brain atrophy, including smaller total (Beta\u2009\u00b1\u2009standard error, \u22120.05\u2009\u00b1\u20090.02; p\u2009=\u20090.014) and cortical gray brain volumes (\u22120.06\u2009\u00b1\u20090.02; p\u2009=\u20090.004), and larger lateral ventricular volumes (0.06\u2009\u00b1\u20090.02; p\u2009=\u20090.006). Additionally, higher RBP4 (\u22120.06\u2009\u00b1\u20090.03; p\u2009=\u20090.042), Fetuin-A (\u22120.06\u2009\u00b1\u20090.03; p\u2009=\u20090.039), and FABP4 (\u22120.09\u2009\u00b1\u20090.03; p\u2009=\u20090.008) concentrations were associated with smaller anterior hippocampal volumes. Most associations remained after additional adjustment for vascular risk factors. In exploratory analyses, higher FABP4 was related to larger total brain in non-obese participants, and to smaller anterior hippocampal volumes in obese participants. Finally, higher adiponectin concentrations were related to smaller cortical gray, only in non-obese participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that adipokines are associated with markers of brain atrophy during midlife. Further studies are needed to replicate these findings and elucidate any potential mechanisms contributing to abnormal brain aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241289043","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:53:02Z","timestamp":1732499582000},"page":"449-458","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-4430","authenticated-orcid":false,"given":"Claudia L","family":"Satizabal","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Framingham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayandra Jung","family":"Himali","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa S","family":"Beiser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Maillard","sequence":"additional","affiliation":[{"name":"Imaging of Dementia and Aging Laboratory and Center for Neurosciences, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S","family":"Vasan","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA"},{"name":"University of Texas School of Public Health, San Antonio, TX, USA"},{"name":"Long School of Medicine, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Imaging of Dementia and Aging Laboratory and Center for Neurosciences, Davis, CA, USA"},{"name":"Department of Neurology, UC Davis School of Medicine, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; 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