{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:10:16Z","timestamp":1793502616787,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) can be optimally managed from a healthcare point of view if detected at a prodromal stage. Amnestic mild cognitive impairment (MCI) is known as prodromal AD, has attracted extensive attention and research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the differences in cognitive function and structural magnetic resonance imaging (MRI) features between men and women with MCI on the basis of A\/T\/N classification system (\u201cA\u201d means amyloid-\u03b2 biomarker, \u201cT\u201d means tau biomarker, and \u201cN\u201d means neurodegeneration biomarker as determined by clinical imaging (e.g., positron emission tomography, magnetic resonance imaging (MRI)) or by the measurement of total tau protein (T-tau) in the cerebrospinal fluid (CSF)) and to further explore the correlation between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>406 MCI subjects were selected from the Alzheimer's Disease Neuroimaging Initiative database and divided into male and female MCI groups. Differences in demographic characteristics, biomarkers, cognitive assessment performance, and regions of interest (ROIs) of structural MRI were compared between the two groups. The correlations between brain structural changes quantified by MRI and cognitive abilities were investigated through linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with male MCI subjects, females had significantly higher T-tau concentration in CSF. There were significant differences in ROIs between the sex groups. In the male MCI group, the average cortical thicknesses of the right posterior cingulate, right anterior cingulate and right supramarginal gyrus were more closely correlated with cognitive function. In the female MCI group, the volume of the right rostral anterior cingulate, and the surface area and average cortical thickness of the right isthmus of the cingulate gyrus were more closely correlated with cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on A\/T\/N classification system, the structural MRI data analysis was closely correlated with the difference of cognitive function from patients with prodromal AD in a sex-dependent manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241289790","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:53:02Z","timestamp":1732499582000},"page":"347-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Valuing the importance of sex differences in prodromal Alzheimer's disease based on structural magnetic resonance imaging"],"prefix":"10.1177","volume":"102","author":[{"given":"Chao","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China"},{"name":"Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Linyi People's Hospital, Linyi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Zhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China"},{"name":"Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Ning","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China"},{"name":"Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgical Intensive Care Unit, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantaishan Hospital, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0621-5558","authenticated-orcid":false,"given":"Mao-Wen","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China"},{"name":"Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging 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