{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:09:09Z","timestamp":1791896949465,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Distinguishing between mild cognitive impairment (MCI) and early dementia requires both neuropsychological and functional assessment that often relies on caregivers\u2019 insights. Contacting a patient's caregiver can be time-consuming in a physician's already-filled workday.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the utility of a brief, machine learning (ML)-enabled digital cognitive assessment, the Digital Clock and Recall (DCR), for detecting functional dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated whether the DCR can help identify individuals at risk of functional deficits as measured by the informant-rated Functional Activities Questionnaire (FAQ) in older individuals including cognitively unimpaired, MCI, and dementia likely due to Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The DCR scaled well with FAQ scores, and ML classifiers trained on multimodal DCR features demonstrated strong performance in predicting functional impairment on a held-out test set. Differences in FAQ scores between DCR-predicted classes were comparable across key demographic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DCR can streamline the clinical decision-making, triage, and intervention planning associated with functional impairment in primary care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241290123","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:53:02Z","timestamp":1732499582000},"page":"329-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Detecting functional impairment with the Digital Clock and Recall"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-324X","authenticated-orcid":false,"given":"Marissa","family":"Ciesla","sequence":"first","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-2276","authenticated-orcid":false,"given":"Claudio","family":"Toro-Serey","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-1275","authenticated-orcid":false,"given":"Ali","family":"Jannati","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"},{"name":"Department of Neurology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-2584","authenticated-orcid":false,"given":"Russell E","family":"Banks","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"},{"name":"Department of Communicative Sciences &amp; Disorders, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-0780","authenticated-orcid":false,"given":"Joyce","family":"Gomes-Osman","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"},{"name":"Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Showalter","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7339-6946","authenticated-orcid":false,"given":"David","family":"Bates","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-7920","authenticated-orcid":false,"given":"Sean","family":"Tobyne","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-0382","authenticated-orcid":false,"given":"Alvaro","family":"Pascual-Leone","sequence":"additional","affiliation":[{"name":"Linus Health, Inc., Boston, MA, USA"},{"name":"Department of Neurology, Harvard Medical School, Boston, MA, USA"},{"name":"Hinda and Arthur Marcus Institute for Aging Research, Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_5_3_2","unstructured":"World Health Organization. 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