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However, their effect on AD pathophysiological markers is unknown. We compared cerebrospinal fluid (CSF) AD biomarker levels among non-demented individuals taking low, intermediate, or high BBB permeable \u03b2-blockers in two samples (ADNI: n\u2009=\u2009216; EPAD: n\u2009=\u200979). We found that CSF amyloid-\u03b2 levels were higher in individuals taking highly permeable \u03b2-blockers in the ADNI sample. This result was not replicated in EPAD, in which diminished levels of pTau181 and tTau were observed. These data suggest that \u03b2-blockers may impact AD pathophysiology.<\/jats:p>","DOI":"10.1177\/13872877241293812","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T05:12:44Z","timestamp":1732511564000},"page":"975-980","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood-brain barrier permeable \u03b2-blockers association with Alzheimer's disease cerebrospinal fluid biomarkers levels in non-demented individuals"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-5744","authenticated-orcid":false,"given":"Mariateresa","family":"Buongiorno","sequence":"first","affiliation":[{"name":"Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain"},{"name":"Neurovascular Diseases Research Group, Vall d'Hebron Research Institute, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"S\u00e1nchez-Benavides","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain"},{"name":"Hospital del Mar Research Institute, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Marzal-Esp\u00ed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fundaci\u00f3 Assistencial M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darly Milena","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain"},{"name":"Neurovascular Diseases Research Group, Vall d'Hebron Research Institute, 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