{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:19:06Z","timestamp":1777396746127,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG062109"],"award-info":[{"award-number":["R01-AG062109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG083735"],"award-info":[{"award-number":["R01-AG083735"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid-\u03b2 (A\u03b2) and hyperphosphorylated tau are crucial biomarkers in Alzheimer's disease (AD) pathogenesis, interacting synergistically to accelerate disease progression. While A\u03b2 initiates cascades leading to tau hyperphosphorylation and neurofibrillary tangles, PET imaging studies suggest a sequential progression from amyloidosis to tauopathy, closely linked with neurocognitive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the complex interactions between A\u03b2 and tau in AD using probabilistic graphical models, assessing how regional tau accumulation is influenced by A\u03b2 burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Anti-A\u03b2 Treatment in Asymptomatic Alzheimer's (A4) study were utilized, involving participants across various cognitive stages and employing both Florbetapir and Flortaucipir as tracers. Tau standardized uptake value ratio values were harmonized across studies, and participants were stratified into quantile groups based on A\u03b2 levels. A LASSO regularized Gaussian graphical model analyzed partial correlations among brain regions to discern patterns of tau accumulation across different A\u03b2 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Statistical analyses revealed significant differences in tau structure among low, medium, and high A\u03b2 groups in both ADNI and A4 cohorts, with graph metrics, such as small-world coefficient, indicating increased tau efficiency as A\u03b2 burden increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that tau accumulates more efficiently with increasing A\u03b2 burden, highlighting an interplay that could inform development of dual-targeting therapies in AD. This study underscores the importance of A\u03b2 and tau interactions in AD progression and supports the hypothesis that targeting both pathologies could be crucial for therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241294084","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:12:39Z","timestamp":1734401559000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global amyloid burden enhances network efficiency of tau propagation in the brain"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2017-3325","authenticated-orcid":false,"given":"Meagan V","family":"Lauber","sequence":"first","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Graduate Program for Neuroscience, Division of Graduate Medical Sciences, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3076-6069","authenticated-orcid":false,"given":"Matteo","family":"Bellitti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3573-8087","authenticated-orcid":false,"given":"Krish","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2689-0259","authenticated-orcid":false,"given":"Varuna H","family":"Jasodanand","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-4491","authenticated-orcid":false,"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Anatomy and Neurobiology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, \rMA, USA"},{"name":"The Framingham Heart Study, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-8644","authenticated-orcid":false,"given":"Vijaya B","family":"Kolachalama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Department of Computer Science, Boston University, Boston, MA, USA"},{"name":"Faculty of Computing &amp; Data Sciences, Boston University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0687-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.03.011"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnagi.2020.00265","article-title":"Mechanisms of pathogenic tau and A\u03b2 protein spreading in Alzheimer\u2019s disease","volume":"12","author":"D\u2019Errico P","year":"2020","unstructured":"D\u2019Errico P, Meyer-Luehmann M. 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