{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:07:04Z","timestamp":1790957224506,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004896","name":"Eisai Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Over 90% of individuals with mild cognitive impairment (MCI) may not receive a timely diagnosis. Understanding community-based practice patterns, where most individuals are seen, is critical to improving patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To understand how patients with MCI and mild dementia due to Alzheimer's disease (AD) are diagnosed and managed in community-based settings, including the use of clinical and cognitive assessments, referrals to dementia-related specialties, and receipt of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study recruited community-based primary care physicians (PCPs) (N\u2009=\u2009177) and neurologists (N\u2009=\u2009147) in August-September 2023, through a verified physician panel with broad geographic representation across the US. Physicians abstracted medical chart data from patients diagnosed with MCI or mild AD within the previous two years. Data collected included use of neurocognitive assessments, biomarker and structural imagine tests, referrals, and treatments. Descriptive statistics were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Medical records for 817 MCI and 467 mild AD patients were abstracted. The mean age was 70.2 years, 56.4% were female, and 67.2% were White. Symptoms were commonly reported by a family member (67.2%). Nearly 1 in 6 patients did not receive any neurocognitive assessments (16.1%), and nearly 1 in 4 did not receive a structural imaging or AD-specific biomarker test (23.7%). AD-specific biomarker tests were more common among patients aged \u226565 (87.1% versus 75.3%; p\u2009&lt;\u20090.05). Less than 1 in 4 patients were referred for cognitive\/behavioral concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As the diagnostic and treatment landscape changes, education on symptom recognition, and physician training on new technologies may facilitate timely diagnoses and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241297128","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T03:16:55Z","timestamp":1732850215000},"page":"1172-1182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Real-world diagnostic, referral, and treatment patterns in early Alzheimer's disease among community-based practices in the United States"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-4113","authenticated-orcid":false,"given":"Timothy R","family":"Juday","sequence":"first","affiliation":[{"name":"US Medical Affairs, HEOR & RWE, Eisai Inc., Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-9184","authenticated-orcid":false,"given":"Ashley","family":"Holub","sequence":"additional","affiliation":[{"name":"Analysis Group, Health Economics and Outcomes Research, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-9132","authenticated-orcid":false,"given":"Soeren","family":"Mattke","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-7453","authenticated-orcid":false,"given":"Keith A","family":"Betts","sequence":"additional","affiliation":[{"name":"Analysis Group, Health Economics and Outcomes Research, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Analysis Group, Health Economics and Outcomes Research, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-5170","authenticated-orcid":false,"given":"Hongjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Analysis Group, Health Economics and Outcomes Research, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Batrla","sequence":"additional","affiliation":[{"name":"US Medical Affairs, HEOR & RWE, Eisai Inc., Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-1112","authenticated-orcid":false,"given":"Feride H","family":"Frech","sequence":"additional","affiliation":[{"name":"US Medical Affairs, HEOR & RWE, Eisai Inc., Nutley, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-5039","authenticated-orcid":false,"given":"Ara S","family":"Khachaturian","sequence":"additional","affiliation":[{"name":"Brain Watch Coalition, Prevent Alzheimer's Disease 2020, Inc. (PAD 20\/20), Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"bibr1-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"bibr2-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200110000-00002"},{"key":"bibr3-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13244"},{"key":"bibr4-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.98.18_supplement.1353"},{"key":"bibr5-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"bibr6-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1159\/000354370"},{"key":"bibr7-13872877241297128","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.23"},{"key":"bibr8-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0069-5"},{"key":"bibr9-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.05.017"},{"key":"bibr10-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01272-z"},{"key":"bibr11-13872877241297128","unstructured":"Alzheimer's Association. 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First practice guidelines for clinical evaluation of Alzheimer\u2019s disease and other dementias for primary and specialty care, https:\/\/aaic.alz.org\/downloads2018\/sun-clinical-practice-guidelines.pdf (2018)."},{"key":"bibr22-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006213"},{"key":"bibr23-13872877241297128","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05246-x"},{"key":"bibr24-13872877241297128","unstructured":"Medicare Coverage Database. 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