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Tau levels were quantified in the nbM and Braak-staging regions. Postmortem brain samples were examined to assess\n                      <jats:sup>18<\/jats:sup>\n                      F-florzolotau binding to tau deposits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EOAD showed a higher overall tau burden, including in the nbM, compared with LOAD. However, nbM tau levels correlated more strongly with cognitive decline in LOAD than EOAD. The relationship between nbM tau and neocortical tau differed between EOAD and LOAD. Histopathology revealed abundant\n                      <jats:sup>18<\/jats:sup>\n                      F-florzolotau labeling of neurofibrillary tangles (NFTs) and ghost tangles in AD nbM samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides the first in vivo PET evidence of differential nbM tau pathology between EOAD and LOAD, with higher accumulation but weaker correlation to cognition in EOAD. The distinct relationships between nbM and cortical tau in EOAD and LOAD suggest divergent pathological trajectories.\n                      <jats:sup>18<\/jats:sup>\n                      F-florzolotau PET successfully visualized NFTs and extracellular ghost tangles in the nbM across AD stages. These findings highlight the importance of considering age of onset when evaluating tau pathology and its clinical correlates in AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241297382","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:55:01Z","timestamp":1732499701000},"page":"1271-1285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Distinct tau pathologies in the nucleus basalis of Meynert between early-onset and late-onset Alzheimer's disease patients revealed by positron emission tomography"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6193-1510","authenticated-orcid":false,"given":"Hisaomi","family":"Suzuki","sequence":"first","affiliation":[{"name":"National Hospital Organization (NHO) Shimofusa Psychiatric Medical Center, Chiba, Japan"},{"name":"Advanced Neuroimaging 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