{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:19:32Z","timestamp":1777396772232,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prodromal dementia is largely underdiagnosed in primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a clinical model for detecting prodromal dementia within the operative boundaries of primary care practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study employed the Functional Activities Questionnaire (FAQ) and Montreal Cognitive Assessment (MoCA) to evaluate a \u201cfunctional-cognitive\u201d step-down screening model, in which the MoCA is administered subsequent to reported symptoms on the FAQ. It classified participants from the Alzheimer's Disease Imaging Initiative to three diagnostic categories: (1) healthy cognition (n\u2009=\u2009396), (2) mild cognitive impairment without conversion (n\u2009=\u2009430), and (3) prodromal dementia assessed 24 months before diagnosis (n\u2009=\u2009164).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analyses indicated that the step-down model (Model 1) performed significantly better than an alternative model that applied the FAQ as a single measure (Model 2) and compared well with another model that administered both screening measures to all participants (Model 3). Gradient Boosting Trees classifications yielded the following estimations for Model 1\/Model 2\/ Model 3, respectively: Sensitivity\u2009=\u20090.87\/0.77\/0.89, Specificity\u2009=\u20090.68\/0.47\/0.70, PPV\u2009=\u20090.73\/0.40\/0.75, NVP\u2009=\u20090.84\/0.81\/0.87, F1 Score\u2009=\u20090.79\/0.52\/0.81, AUC\u2009=\u20090.78\/0.67\/0.79.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These analyses support the proposed model. The study offers algorithms for validated measures, which were developed from a well characterized clinical sample. Their accuracy will likely improve further with new data from diverse clinical settings. These results can serve primary care in a timely manner in light of the recent advances in pharmacological treatment of dementia and the expected increase in demand for screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241297410","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T03:02:23Z","timestamp":1733194943000},"page":"1239-1248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stepwise identification of prodromal dementia: Testing a practical model for primary care"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-1113","authenticated-orcid":false,"given":"Boaz","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Counseling and School Psychology, University of Massachusetts Boston, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna","family":"D'Ambrozio","sequence":"additional","affiliation":[{"name":"Department of Counseling and School Psychology, University of Massachusetts Boston, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"bibr1-13872877241297410","unstructured":"Boustani M, Peterson B, Harris R, et al. 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