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In the present study, we examined whether WTC exposure duration was associated with cerebral amyloidosis in WTC responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      WTC responders (aged 44\u201365 years) who varied in exposure duration but did not use personalized protective equipment were assessed using positron-emission tomography with [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben. The outcome was the cortical [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben burden, measured using regional standardized uptake value ratios (SUVRs) in 34 Desikan-Killiany regions of interest. Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      and generalized linear models were used to estimate correlations between WTC exposure duration and cortical [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben SUVR. Cognitive and behavioral symptoms were measured. Magnetic resonance imaging was used to measure cortical thickness and diffusivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of imaged responders was 56 years old. WTC exposure duration was associated with olfactory [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben SUVR (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.43, p\u2009=\u20090.011), which was in turn associated with elevated [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben SUVR in ventral regions (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.41, p\u2009=\u20090.016). Cortical [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Florbetaben in ventral regions was associated with reduced response speed (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.72, p\u2009&lt;\u20090.001), was co-located with cortical diffusivity across regions in the parietal and frontal lobes and reduced cortical thickness in the isthmus cingulate (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.53, p\u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low-grade amyloidosis in the olfactory and frontal lobes was associated with WTC exposure duration. Future work should examine whether low-grade amyloidosis is correlated with the location or distribution of neurofibrillary tangles in WTC responders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241302350","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T03:22:26Z","timestamp":1732850546000},"page":"383-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study"],"prefix":"10.1177","volume":"103","author":[{"given":"Minos","family":"Kritikos","sequence":"first","affiliation":[{"name":"Program in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Health Sciences Center, Stony Brook, NY, 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