{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:45:50Z","timestamp":1789926350469,"version":"4.0.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG064228"],"award-info":[{"award-number":["R01AG064228"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG060049"],"award-info":[{"award-number":["R01AG060049"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG082073"],"award-info":[{"award-number":["R01AG082073"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066530"],"award-info":[{"award-number":["P30AG066530"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG052350"],"award-info":[{"award-number":["P01AG052350"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood pressure (BP) variability (BPV) and time in target range (TTR) are emerging vascular risk factors for dementia, independent of traditionally targeted mean BP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Determine whether BPV or TTR is most strongly associated with cognitive risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this post hoc analysis of the SPRINT trial, 8034 participants underwent repeated BP measurement and cognitive testing at baseline and follow-up. Visit-to-visit BPV was calculated as average real variability. TTR was the percent of time in desired treatment arm target range (standard: 120\u2013140\u2005mmHg systolic BP; intensive: 110\u2013130\u2005mmHg systolic BP). Adjudicated clinical outcomes were no cognitive impairment, mild cognitive impairment (MCI), and probable dementia. We investigated a direct comparison of BPV and TTR in predicting cognitive risk, stratified by BP treatment group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated BPV was associated with increased risk for MCI (adjusted HR: 1.21 [95% CI 1.10, 1.33],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) and MCI\/dementia (HR: 1.17 [95% CI 1.07, 1.27],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) in the standard group, and dementia (HR: 1.17 [95% CI 1.01, 1.36],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.039) in the intensive group. Higher TTR was related to lower dementia risk (HR: 0.72 [95% CI 0.60, 0.86],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) in the intensive group only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Visit-to-visit BPV outperformed TTR in predicting risk for MCI and MCI\/dementia. TTR was more strongly associated with dementia risk under intensive treatment. Findings were independent of mean BP in a cohort with rigorously controlled BP and suggest newer aspects of BP control may be harnessed to further reduce cognitive risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial information<\/jats:title>\n                    <jats:p>ClinicalTrials.gov; NCT01206062.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241303378","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:16:28Z","timestamp":1734401788000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-0628","authenticated-orcid":false,"given":"Isabel J","family":"Sible","sequence":"first","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-0658","authenticated-orcid":false,"given":"Daniel A","family":"Nation","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"},{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0008"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21356"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10551"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.1"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00690-0"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1387"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013841"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026739"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200302"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18479"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20627-4"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230930"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012065"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161172"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac128"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022206"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1166554"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20355"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20711"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21413"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.1.40"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0074"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0178"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14314"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09788"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.01.014"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2022.2118662"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_5_36_2","unstructured":"R Core Team. 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