{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:48:58Z","timestamp":1790138938184,"version":"4.0.1"},"reference-count":60,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between subtle cognitive decline and Alzheimer's disease (AD) pathology as measured by biomarkers in settings outside of specialty memory clinics is not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how subtle longitudinal cognitive decline relates to neuroimaging biomarkers in individuals drawn from a population-based study in an economically depressed, small-town area in southwestern Pennsylvania, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A subset of participants without dementia (N\u2009=\u2009115, age 76.53 years\u2009\u00b1\u20096.25) from the Monongahela Youghiogheny Healthy Aging Team (MYHAT) study completed neuroimaging including magnetic resonance imaging (MRI) measures of AD-signature region cortical thickness and white matter hyperintensities (WMH), Pittsburgh compound B (PiB)-positron emission tomography (PET) for amyloid-\u03b2 (A\u03b2) deposition, and [\n                      <jats:sup>18<\/jats:sup>\n                      F]AV-1451-PET for tau deposition. Neuropsychological evaluations were completed at multiple timepoints up to 11 years prior to neuroimaging. A\u03b2 positivity was determined using a regional approach. We used linear mixed models to examine neuroimaging biomarker associations with retrospective cognitive slopes in five domains and a global cognitive composite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among A\u03b2(+) participants (38%), there were associations between (i) tau Braak III\/IV and language decline (p\u2009&lt;\u20090.05), (ii) cortical thickness and both memory decline (p\u2009&lt;\u20090.001) and global cognitive decline (p\u2009&lt;\u20090.01), and (iii) WMH and decline in executive function (p\u2009&lt;\u20090.05) and global cognition (p\u2009&lt;\u20090.05). Among A\u03b2(-) participants, there was an association between tau Braak III\/IV and decline on tests of attention\/psychomotor speed (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings confirm an A\u03b2-dependent early AD biomarker pathway, and suggest a possible A\u03b2-independent, non-AD process underlying subtle cognitive decline in a population-based sample of older adults without dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241303926","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T01:58:31Z","timestamp":1734659911000},"page":"570-581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Multimodal neuroimaging biomarkers and subtle cognitive decline in a population-based cohort without dementia"],"prefix":"10.1177","volume":"103","author":[{"given":"Andrea M","family":"Weinstein","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Research &amp; Infrastructure Service Enterprise (RISE), Internal Medicine, Eastern Virginia Medical School, Norfolk, \rVA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Chou H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M","family":"Laymon","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelesh K","family":"Nadkarni","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Ilyas","family":"Kamboh","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Elizabeth Shaaban","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa A","family":"Gogniat","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ganguli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-1374","authenticated-orcid":false,"given":"Beth E","family":"Snitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Global action plan on the public health response to dementia 2017-2025","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. 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