{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:21:00Z","timestamp":1777396860617,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Youth Project of China-Japan Friendship Hospital","award":["No.2020-1-QN-8"],"award-info":[{"award-number":["No.2020-1-QN-8"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-NHLHCRF-LX-02-0123"],"award-info":[{"award-number":["2022-NHLHCRF-LX-02-0123"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Youth Program, 81503519"],"award-info":[{"award-number":["Youth Program, 81503519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elucidate the potential mechanisms of Sheng-Hui-Yi-Zhi (SHYZ) for the treatment of AD and explore the effective substances of SHYZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Liquid chromatography-mass spectrometry (LC-MS) was used to identify the active components of SHYZ. Network pharmacology was employed to predict the potential targets and pathways of SHYZ in the treatment of AD. SAMP8 mice were used as a model for AD and were treated with SHYZ. The Morris water maze was utilized to assess the learning and memory capabilities of mice. Additionally, the levels of TNF-\u03b1, IL-1\u03b2, and IL-6 in the brain hippocampus of mice were quantified using ELISA. The protein expression of PI3 K\/p-PI3 K, AKT\/p-AKT, MAPK38\/p-MAPK38, and NF\u03baB p65\/p-NF\u03baB p65 in the hippocampus was analyzed using Western blotting. Additionally, qRT-PCR was employed to assess the gene expressions of TNF-\u03b1, IL-1\u03b2, and IL-6 in the hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The network pharmacological prediction results showed that the treatment of AD with SHYZ was closely related to the inhibition of inflammatory response. Behavioral experiments revealed that SHYZ significantly reduced the time taken to escape, increased the number of times the platform was crossed, and prolonged the residence time in the target quadrant. Meanwhile, SHYZ treatment suppressed the expression of A\u03b2\n                      <jats:sub>1\u221242<\/jats:sub>\n                      protein and inflammatory factors. SHYZ significantly inhibited the expression of proteins of PI3 K, AKT, MAPK p38, and NF-\u03baB p65.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      SHYZ has been shown to effectively ameliorate learning and memory impairment in SAMP8 AD mice by inhibiting the expression of A\u03b2\n                      <jats:sub>1\u221242<\/jats:sub>\n                      and reducing the increase of inflammatory factors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241305744","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T05:40:29Z","timestamp":1736314829000},"page":"666-678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating network pharmacology and component analysis to investigate the potential mechanisms of Sheng-Hui-Yi-Zhi decoction in the treatment of Alzheimer\u2019s disease"],"prefix":"10.1177","volume":"103","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Department of Healthcare, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-li","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Peking University People's Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Education, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Institute, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-bing","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Healthcare, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5708-6259","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Department of Healthcare, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-023-00504-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2410"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2013.34190"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1039856218762308"},{"key":"e_1_3_4_9_2","first-page":"1479","article-title":"Cholinesterase inhibitors as Alzheimer's therapeutics (Review)","volume":"20","author":"Sharma K","year":"2019","unstructured":"Sharma K. 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