{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:23:10Z","timestamp":1790785390740,"version":"4.1.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108013, 82327809"],"award-info":[{"award-number":["82020108013, 82327809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"STI2030-Major Projects","award":["2022ZD0211800"],"award-info":[{"award-number":["2022ZD0211800"]}]},{"name":"Sino-German Cooperation Grant","award":["M-0759"],"award-info":[{"award-number":["M-0759"]}]},{"name":"Shenzhen Bay Scholars Program and Tianchi Scholars Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma biomarkers demonstrated potential in identifying amyloid pathology in early Alzheimer's disease. Different subtypes of subjective cognitive decline (SCD) may lead to different cognitive impairment conversion risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the differences of plasma biomarkers in SCD subtypes individuals, which were unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The 347 individuals were involved, including 93 normal controls (NC), 76 single memory domain SCD (sd-SCD), 79 multidomain SCD (md-SCD), 55 mild cognitive impairment and 44 dementia. We investigated plasma biomarkers (A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , p-tau181, p-tau217, NfL, and GFAP) and neuropsychological scales in the baseline and follow-up. The Kaplan-Meier survival analysis and Cox proportional hazards model were performed to investigate the risk of cognitive decline conversion. The t-test, Mann-Whitney U and multiple linear regression analysis were employed to evaluate the rate of change and correlation between PET-SUVR and plasma biomarker change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In cognitively normal subjects, md-SCD exhibited lower A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      and higher p-tau181 and p-tau217 levels. Kaplan-Meier survival analysis revealed that md-SCD group exhibited a higher risk of cognitive decline conversion compared to NC and sd-SCD. Within SCD subgroups, those with positive GFAP status showed higher conversion risk than negative. In the Cox model, the risk of conversion in the md-SCD group was 2.77 times that of sd-SCD. The md-SCD group demonstrated a faster rate of A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      decline than sd-SCD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study utilized plasma biomarkers to highlight the significance of staging in SCD. In cognitively normal subjects, md-SCD presents a higher risk of cognitive decline than sd-SCD, providing a valuable reference and convenient tool for early identification of individuals at risk for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241309105","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T04:36:13Z","timestamp":1736483773000},"page":"1060-1074","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Differences of longitudinal plasma biomarkers between single memory domain and multidomain subjective cognitive decline: Evidence from SILCODE"],"prefix":"10.1177","volume":"103","author":[{"given":"Min","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 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