{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T05:39:58Z","timestamp":1785649198097,"version":"3.56.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171198"],"award-info":[{"award-number":["82171198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Science Technology Major Project","award":["2018SHZDZX01"],"award-info":[{"award-number":["2018SHZDZX01"]}]},{"name":"STI2030-Major Projects","award":["2022ZD0213800"],"award-info":[{"award-number":["2022ZD0213800"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary formic acid (FA) has been reported to be a biomarker for Alzheimer's disease (AD). However, the association between FA and pathological changes in memory clinic patients is currently unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate associations between FA and pathological changes across different cognitive statuses in memory clinic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of patients with mild cognitive impairment (MCI-A\u03b2- n\u2009=\u200937, MCI-A\u03b2+ n\u2009=\u200933), AD dementia (n\u2009=\u200939), and cognitively normal subjects (CN-A\u03b2- n\u2009=\u200998, CN-A\u03b2+ n\u2009=\u200950) were included. Comprehensive neuropsychological assessment, urinary FA, AD-related plasma biomarkers, MRI scans, [\n                      <jats:sup>18<\/jats:sup>\n                      F]-flurbetapir and [\n                      <jats:sup>18<\/jats:sup>\n                      F]-FDG PET scan data were collected from all participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Urinary FA levels were higher in patients with MCI and AD than in CN subjects and higher in A\u03b2+ (CN- A\u03b2+, MCI-A\u03b2+, AD dementia) subjects than in A\u03b2-subjects (CN- A\u03b2-, MCI-A\u03b2-). Urinary FA was positively associated with cerebral A\u03b2 deposition and negatively associated with glucose metabolism, both at the global level and in multiple regions of interest cortical regions in participants with different cognitive statuses. Additionally, urinary FA levels were positively correlated with the severity of white matter hyperintensities and hippocampal atrophy. Urinary FA combined with age, Mini-Mental State Examination, plasma p-tau181, and neuro\ufb01lament light chain could be used to predict A\u03b2 deposition in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary FA is associated with brain pathological changes in memory clinic patients, including cerebral A\u03b2 deposition, glucose metabolism, white matter hyperintensities, and hippocampal atrophy. It could be used as a biomarker for the early diagnosis of AD and predicting A\u03b2 deposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877241309117","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T04:37:53Z","timestamp":1736483873000},"page":"1102-1111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary formic acid is associated with cerebral amyloid deposition and glucose metabolism in memory clinic patients"],"prefix":"10.1177","volume":"103","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengfeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqiao","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-8047","authenticated-orcid":false,"given":"Qihao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120861"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.04.506"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12283"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.994036"},{"key":"e_1_3_5_7_2","first-page":"529","article-title":"Urinary 8-hydroxy-2'-deoxyguanosine level and plasma paraoxonase 1 activity with Alzheimer's disease","volume":"50","author":"Zengi O","year":"2011","unstructured":"Zengi O, Karakas A, Ergun U, et al. 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