{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:25:23Z","timestamp":1789503923130,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008436","name":"National Foundation for Medical Research and Innovation","doi-asserted-by":"publisher","award":["A-0006310-00-00"],"award-info":[{"award-number":["A-0006310-00-00"]}],"id":[{"id":"10.13039\/100008436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Blood-brain barrier (BBB) dysfunction is suggested to be a potential mediator between vascular risk factors and cognitive impairment, leading to vascular cognitive impairment.\n                    <jats:bold>Objective:<\/jats:bold>\n                    To investigate the relationships between age, sex, and vascular risk factors and BBB water permeability as well as their relationship with cognition.\n                    <jats:bold>Methods:<\/jats:bold>\n                    To measure BBB permeability, a novel arterial spin labelling MRI technique (ME-ASL) was applied to derive the time of exchange (Tex), arterial time transit (ATT), and cerebral blood flow (CBF). The association of potential risk factors, such as age, sex, body mass index (BMI), blood pressure (BP), and medical history, with these BBB parameters were assessed in 144 community-dwelling adults (median age 59 years, 57% females). The relationship between BBB permeability and cognitive performance measured by the Montreal Cognitive Assessment (MoCA) was also assessed.\n                    <jats:bold>Results:<\/jats:bold>\n                    We found that increased BMI was significantly associated with decreased CBF (\u03b2\u2009=\u2009\u22120.06). Systolic BP and diastolic BP showed significant associations with all ASL parameters; systolic BP was negatively correlated with Tex (\u03b2\u2009=\u2009\u22120.02) and CBF (\u03b2\u2009=\u2009\u22120.01) but positively with ATT (\u03b2\u2009=\u20090.02). Diastolic BP was negatively associated with Tex (\u03b2\u2009=\u2009\u22120.03) and CBF (\u03b2\u2009=\u2009\u22120.03) but positively with ATT (\u03b2\u2009=\u20090.03). MoCA scores had a borderline significant association with Tex (OR\u2009=\u20091.51) and a significant association with CBF (OR\u2009=\u20091.84), which became non-significant after adjusting for confounders.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These outcomes underscore the potential of using ME-ASL, warranting further research to strengthen these findings.\n                  <\/jats:p>","DOI":"10.1177\/13872877251314138","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T20:54:53Z","timestamp":1736974493000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between potential risk factors and blood-brain barrier water permeability in middle-aged and older adults"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-700X","authenticated-orcid":false,"given":"Mervin","family":"Tee","sequence":"first","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-9443","authenticated-orcid":false,"given":"Beatriz E","family":"Padrela","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands"},{"name":"Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Dupeyron","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam 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