{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:02Z","timestamp":1777396982680,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Taichung Tzu Chi Hospital","award":["TTCRD 112-04"],"award-info":[{"award-number":["TTCRD 112-04"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While cerebrovascular hemodynamics exhibits critical interplay with the pathogenesis of dementia, limited articles have examined the impact of vertebrobasilar (VB) hemodynamics on cerebral blood flow (CBF), and to what extent it varies by dementia subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the associations between VB hemodynamics and CBF by dementia subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research recruited a total of 120 dementia patients [43 subcortical ischemic vascular dementia (SIVD); 59 Alzheimer's disease (AD); 18 mixed dementia] and 40 older adults with normal cognition and compared their transcranial doppler (TCD) flow parameters and arterial spin labeling-measured CBF. Using the partial correlation analysis, the associations between TCD parameters and CBF values were explored among the defined subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A higher VB pulsatility index (PI) was related to lower parietal CBF and lower VB end-diastolic velocity (EDV). Moreover, the significance of flow parameters in the basilar artery (BA) to parietal CBF was identified: peak-systolic velocity (PSV) unanimously showed positive correlations among all subgroups except SIVD, and both PSV and EDV showed positive correlations in AD. Of note, there were more noticeable \u201cBA flow-frontoparietal CBF\u201d associations among the high than low VB PI group, and AD than SIVD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings indicate that VB-resistance-related parietal vulnerability and topological CBF associations vary by dementia subtypes. Given VB hemodynamics-CBF relationships, the current research extends our understanding of the vasocognopathic effects among dementia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251314140","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T01:10:54Z","timestamp":1740445854000},"page":"106-115","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A higher vertebrobasilar pulsatility index is associated with lower parietal perfusion in Alzheimer's disease"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9799-1836","authenticated-orcid":false,"given":"Shu-Wen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan (R.O.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-3339","authenticated-orcid":false,"given":"Yen-Hsuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Psychology, National Chung Cheng University, Chiayi, Taiwan (R.O.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1635-9635","authenticated-orcid":false,"given":"Jir-Jei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan (R.O.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-1313","authenticated-orcid":false,"given":"Min-Chien","family":"Tu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan (R.O.C.)"},{"name":"Department of Neurology, China Medical University Hospital, Taichung, Taiwan (R.O.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.12.009"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.573324"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225016254"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.160"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.02.003"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.09.002"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.12.018"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617717001175"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000535422"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216162"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237740"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00904-7"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.10.053"},{"key":"e_1_3_4_17_2","first-page":"676","article-title":"Factor structure and explanatory variables of the Mini-Mental State Examination (MMSE) for elderly persons in Taiwan","volume":"100","author":"Shyu Y-IL","year":"2001","unstructured":"Shyu Y-IL, Yip P-K. Factor structure and explanatory variables of the Mini-Mental State Examination (MMSE) for elderly persons in Taiwan. J Formos Med Assoc 2001; 100: 676\u2013683.","journal-title":"J Formos Med Assoc"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175143"},{"key":"e_1_3_4_19_2","first-page":"23","article-title":"Research criteria for subcortical vascular dementia in clinical trials","volume":"59","author":"Erkinjuntti T","year":"2000","unstructured":"Erkinjuntti T, Inzitari D, Pantoni L, et al. Research criteria for subcortical vascular dementia in clinical trials. J Neural Transm Suppl 2000; 59: 23\u201330.","journal-title":"J Neural Transm Suppl"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490510088009"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.140"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215405"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230763"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_3_4_27_2","unstructured":"Schmidt P. Bayesian inference for structured additive regression models for large-scale problems with applications to medical imaging. Dissertation LMU M\u00fcnchen: Faculty of Mathematics Computer Science and Statistics 2017."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00190-4"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339234"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000087"},{"key":"e_1_3_4_31_2","first-page":"681903","article-title":"Study of posterior cerebral artery in human cadaveric brain","volume":"2015","author":"Gunnal S","year":"2015","unstructured":"Gunnal S, Farooqui M, Wabale R. Study of posterior cerebral artery in human cadaveric brain. Anat Res Int 2015; 2015: 681903.","journal-title":"Anat Res Int"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rxeng.2021.10.004"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328354ff0a"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.27.5.929"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034338"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10551"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000057848"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103642"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.614453"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2692"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.655837"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251314140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251314140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251314140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:43Z","timestamp":1777370983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251314140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/13872877251314140"],"URL":"https:\/\/doi.org\/10.1177\/13872877251314140","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]}}}