{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:24:24Z","timestamp":1777397064970,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    We assessed the severity of amyloid-\u03b2 accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n\u2009=\u200947) with Alzheimer's disease (AD). The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while the percentage of WML area relative to brain parenchymal area was determined using magnetic resonance imaging. Cognitive decline was positively correlated with WML severity (\n                    <jats:italic toggle=\"yes\">r\u2009<\/jats:italic>\n                    =\u20090.50,\n                    <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                    =\u20090.042) but not mcSUVR (A\u03b2 accumulation). Managing vascular risk factors can prevent cognitive decline in patients with AD.\n                  <\/jats:p>","DOI":"10.1177\/13872877251316516","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T23:47:11Z","timestamp":1739749631000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["White matter lesions rather than amyloid-\u03b2 burden are associated with cognitive decline in Alzheimer's disease"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-9189","authenticated-orcid":false,"given":"Hiroo","family":"Kasahara","sequence":"first","affiliation":[{"name":"Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of General Education 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