{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:24:58Z","timestamp":1777397098984,"version":"3.51.4"},"reference-count":76,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RP12117A858EE67A"],"award-info":[{"award-number":["RP12117A858EE67A"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite dementia with Lewy bodies (DLB) being the second most common form of neurodegenerative dementia, more than 80% of DLB cases are initially misdiagnosed. Alpha-synuclein (a-syn) and tau species have been detected in peripheral tissues and biological fluids of DLB patients and among different biological fluids, saliva represent an easely accessible and non-invasive source for biomarker detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate salivary a-syn and tau species as molecular disease biomarkers, assessing their potential in the diagnosis of DLB and in the differential diagnosis on respect to Alzheimer's disease (AD) and Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured total and oligomeric a-syn, total-tau, and S199-phosphorylated-tau (pS199-tau) in the saliva of 21 DLB, 20 AD, 20 PD patients, and 20 healthy subjects (HS) using quantitative enzyme-linked immunosorbent assay (ELISA) analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Salivary total a-syn was not significantly changed between the different groups, whereas all pathological groups had a higher oligomeric a-syn concentration than HS. Salivary total-tau concentration was higher in all the pathological groups than HS, whereas the concentrations did not differ among patients\u2019 groups. Conversely, salivary levels of pS199-tau was higher in DLB and AD patients than in HS and PD patients. Both correlation matrix and principal component analysis showed that core clinical DLB features were related to a-syn pathology, while cognitive decline was associated with salivary levels of pS199-tau in both DLB and AD patients. Receiver operating characteristic analysis reported high diagnostic accuracy for both a-syn oligomers and pS199-tau, between DLB and HS, and an adequate accuracy between DLB and PD. Conversely, the diagnostic accuracy was not optimal between DLB patients and AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings provide preliminary evidence that salivary a-syn and tau species might be promising in identifying DLB patients on respect to PD patients and HS, while the diagnostic potential is limited on respect to AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251317720","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:23:13Z","timestamp":1741936993000},"page":"452-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-5938","authenticated-orcid":false,"given":"Fabrizia","family":"D\u2019Antonio","sequence":"first","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"},{"name":"Cognitive and Motor Rehabilitation and Neuroimaging Unit, IRCCS Fondazione Santa Lucia, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-7007","authenticated-orcid":false,"given":"Giorgio","family":"Vivacqua","sequence":"additional","affiliation":[{"name":"Department of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Roma, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Serrentino","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyna","family":"Nalepa","sequence":"additional","affiliation":[{"name":"Department of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Roma, Roma, Italy"},{"name":"Laboratory of Molecular Basis of Neurodegeneration, Mossakowski Medical Research Institute, Polish Academy of Science, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Skweres","sequence":"additional","affiliation":[{"name":"Department of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Roma, Roma, Italy"},{"name":"Laboratory of Molecular Basis of Neurodegeneration, Mossakowski Medical Research Institute, Polish Academy of Science, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Peconi","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-9805","authenticated-orcid":false,"given":"Maria Ilenia","family":"De Bartolo","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Panigutti","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Sepe Monti","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Talarico","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Fabbrini","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.111"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0350-6"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804766-8.00009-1"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afi190"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30074-1"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3579"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt274"},{"key":"e_1_3_5_11_2","article-title":"Dementia with Lewy bodies research consortia: a global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group","volume":"13","author":"D\u2019antonio F","year":"2021","unstructured":"D\u2019antonio F, Kane JPM, Iba\u00f1ez A, et al. Dementia with Lewy bodies research consortia: a global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group. Alzheimers Dement (Amst) 2021; 13: e12235.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.05.004"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30153-X"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1016-8"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14698"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005166"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12597"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac229"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.015"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1157-y"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.2.156"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0082-1"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5324-y"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160322"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00408"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081654"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519869700"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01175-w"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02160-8"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0665-2"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28143"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26550"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110731"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14070352"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106442"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28976"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29246"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1014305"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050595"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071702"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1965"},{"issue":"7","key":"e_1_3_5_45_2","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awr015","article-title":"Salivary \u03b1-synuclein and DJ-1: potential biomarkers for Parkinson\u2019s disease","volume":"134","author":"Devic I","year":"2011","unstructured":"Devic I, Hwang H, Edgar JS, et al. Salivary \u03b1-synuclein and DJ-1: potential biomarkers for Parkinson\u2019s disease. Brain 2011; 134(Pt 7): e178.","journal-title":"Brain"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.03.003"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12772"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150859"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137330"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0792"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004146"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094823"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200259"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014176"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:2:225"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9358-8_15"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.001"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.08.012"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458506ms1288sr"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0781-z"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.06.014"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03281-3"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly059"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0608-7"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28994"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001173"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4222"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.06.018"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.10.013"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa413"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.12.031"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00176-9"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00622-7"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws234"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz311"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0852-9"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28941"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251317720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251317720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251317720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:53Z","timestamp":1777370993000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251317720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/13872877251317720"],"URL":"https:\/\/doi.org\/10.1177\/13872877251317720","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}