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The resulting features are fed through a multi-stage pipeline to determine efficient classification configurations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We evaluated the system on large real-world datasets, achieving above 90% and 70% weighted average F1 scores for two-class (AD versus normal controls) and three-class (AD versus mild cognitive impairment versus normal controls) classification tasks, respectively. Model performance remains stable across different population characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study introduces a robust, non-invasive method for gauging the cognitive status of AD and MCI patients from speech samples, with the potential of generalizing effectively to multiple types of diseases\/disorders which may burden language.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251319401","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T01:14:49Z","timestamp":1740532489000},"page":"656-666","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Linguistic cues for automatic assessment of Alzheimer\u2019s disease across languages"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7877-6517","authenticated-orcid":false,"given":"Vassiliki","family":"Rentoumi","sequence":"first","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"Department of Financial and Management Engineering, School of Engineering, University of the Aegean, Chios, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikiforos","family":"Pittaras","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Admir","family":"Demiraj","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Sali","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Papatriantafyllou","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Griziotis","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemis","family":"Chardouveli","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Pattakos","sequence":"additional","affiliation":[{"name":"LANGaware Inc, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Paliouras","sequence":"additional","affiliation":[{"name":"NCSR Demokritos, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Neurocognitive disorders in aging","author":"Kempler D","year":"2005","unstructured":"Kempler D. 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