{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:26:04Z","timestamp":1777397164574,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JSPS KAKENHI","award":["20K11014"],"award-info":[{"award-number":["20K11014"]}]},{"DOI":"10.13039\/501100007418","name":"Ajinomoto Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The number of patients with dementia is increasing worldwide. In Japan, dementia is the most significant reason recognized for people requiring nursing care. Protein is one of the possible preventive nutrients for dementia; however, adequate intake levels can differ according to usual protein intakes and protein sources.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the relationships between disability-adjusted life years (DALYs) for Alzheimer's disease and protein or amino acid intakes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Global Burden of Disease Study data (DALYs for each sex and age group in each year) and de-identified individual records from the National Health and Nutrition Survey Japan (data from 46,831 subjects) from 2001 to 2019 were used. Multiple regression analyses were conducted to assess the relationships between DALYs and protein or amino acid intakes with lifestyle factors and sociodemographic index as confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher protein-to-energy ratios were correlated with lower DALYs in women in their 70\u2005s (partial regression coefficient [Coeff.]\u2009=\u2009\u2212349.488,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), in men in their 60\u2005s (Coeff.\u2009=\u2009\u221251.484), and in both sexes combined in their 60\u2005s (Coeff.\u2009=\u2009\u221226.696,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) even after adjusting for other possible nutrient intakes. Additionally, elevated isoleucine, lysine, tyrosine, histidine, arginine, alanine, asparagine, and glycine levels were correlated with lower DALYs in women in their 70\u2005s (Coeff.\u2009=\u2009\u22122.752 to \u22120.141).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adequate protein and specific amino acid intakes may be associated with DALYs for Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251319535","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:23:22Z","timestamp":1741937002000},"page":"709-719","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations of dietary protein and amino acid intakes with disability-adjusted life years for Alzheimer's disease in Japanese people"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-2956","authenticated-orcid":false,"given":"Kazuko","family":"Ishikawa-Takata","sequence":"first","affiliation":[{"name":"Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4508-2869","authenticated-orcid":false,"given":"Kazuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Research Institute for Bioscience Products &amp; Fine Chemicals, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-9328","authenticated-orcid":false,"given":"Takayuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Research &amp; Business Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Research &amp; Business Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-4690","authenticated-orcid":false,"given":"Hisamine","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Business Strategy &amp; Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4065-2349","authenticated-orcid":false,"given":"Shinobu","family":"Okada","sequence":"additional","affiliation":[{"name":"School of Nursing, Kawasaki City College of Nursing, Kawasaki, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. 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