{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:27:15Z","timestamp":1777397235060,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM22\/00219"],"award-info":[{"award-number":["CM22\/00219"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM22\/00166"],"award-info":[{"award-number":["CM22\/00166"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the arrival of new disease-modifying treatments for Alzheimer's disease (AD), feasible cognitive tests, also for illiterate patients, are needed to screen those requiring deeper evaluation among individuals presenting with memory complaints. The TMA-93, a brief binding memory test, has proven useful for diagnosing early AD, and is supported by normative data that accounts for age and cognitive reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the sensitivity of different TMA-93 cutoffs in detecting AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on a biobank sample of patients with confirmed AD pathology via amyloid PET or cerebrospinal fluid (CSF) biomarkers. The sensitivity of six TMA-93 cutoffs was evaluated: the 10th, 15th, and 20th percentiles based on traditional norming (TN) and regression-based norming (RBN). False negatives (FN) characteristics were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 270 AD-positive patients (96 by amyloid-PET, 174 by CSF biomarkers) were included, comprising 224 with mild cognitive impairment and 46 with mild dementia. The 15th percentile using RBN demonstrated substantial sensitivity (80.4%), higher than that of the 10th percentile, and also provided a more uniform distribution across normative groups compared to the TN approach. Higher global cognition (Mini-Mental State Examination score) and, in patients over 70, lower cognitive reserve (Cognitive Reserve Questionnaire), were linked to a greater likelihood of FN results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 15th percentile cutoff based on RBN, accounting for age and cognitive reserve, improves sensitivity for detecting AD pathology, making it a valuable screening tool for memory complaints. Future normative data from biomarker-negative subjects may enhance the sensitivity of cognitive tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251325759","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T16:45:12Z","timestamp":1742575512000},"page":"65-76","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["TMA-93 (binding by images): Cutoffs optimization based on Alzheimer's disease biomarkers"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-4601","authenticated-orcid":false,"given":"Jos\u00e9 Enrique","family":"Arriola-Infante","sequence":"first","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain"},{"name":"Department of Neurology, Torrec\u00e1rdenas University Hospital, Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4826-262X","authenticated-orcid":false,"given":"Ernesto","family":"Garc\u00eda-Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-0255","authenticated-orcid":false,"given":"David","family":"Garc\u00eda-Sol\u00eds","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2669-1562","authenticated-orcid":false,"given":"Alba Marta","family":"Mar\u00edn-Caba\u00f1as","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-1427","authenticated-orcid":false,"given":"Andrea","family":"Luque-Tirado","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6188-7027","authenticated-orcid":false,"given":"\u00c1ngela","family":"Almod\u00f3var-Sierra","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Bernal","family":"S\u00e1nchez-Arjona","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-6548","authenticated-orcid":false,"given":"Didier","family":"Maillet","sequence":"additional","affiliation":[{"name":"Service de Neurologie \u00e0 orientation oncologique, H\u00f4pital Saint-Louis (AP-HP), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-1037","authenticated-orcid":false,"given":"Emilio","family":"Franco-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2016.1250211"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721001016"},{"key":"e_1_3_5_6_2","article-title":"Alzheimer's disease drug development pipeline: 2023","volume":"9","author":"Cummings J","year":"2023","unstructured":"Cummings J, Zhou Y, Lee G, et al. 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