{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:36Z","timestamp":1777397136429,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the STI2030-Major Projects","award":["2021ZD0201802"],"award-info":[{"award-number":["2021ZD0201802"]}]},{"name":"Key Project of the National Natural Science Foundation of China","award":["U20A20354"],"award-info":[{"award-number":["U20A20354"]}]},{"name":"Beijing Brain Initiative from Beijing Municipal Science & Technology Commission","award":["Z201100005520017"],"award-info":[{"award-number":["Z201100005520017"]}]},{"name":"the grant from the Chinese Institutes for Medical Research","award":["CX23YZ15"],"award-info":[{"award-number":["CX23YZ15"]}]},{"name":"the National Key Scientific Instrument and Equipment Development Project","award":["31627803"],"award-info":[{"award-number":["31627803"]}]},{"name":"the Key Project of the National Natural Science Foundation of China","award":["81530036"],"award-info":[{"award-number":["81530036"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>More than 60 independent single-nucleotide polymorphisms (SNPs) have been associated with Alzheimer's disease risk by genome-wide association studies in European.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to confirm these SNPs in Chinese Han populations and investigate the utility of these genetic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Altogether 1595 late-onset Alzheimer's disease (LOAD) patients and 2474 controls from Chinese population were recruited. We replicated the association of 68 SNPs with LOAD and established polygenetic risk score (PRS) prediction model using significant SNPs. Meta-analysis for\n                      <jats:italic toggle=\"yes\">MS4A6A<\/jats:italic>\n                      rs610932 and\n                      <jats:italic toggle=\"yes\">PICALM<\/jats:italic>\n                      rs3851179 were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to our findings, 14 out of 68 SNPs are validated significantly associated with LOAD (adjusted p\u2009&lt;\u20090.05) after adjusting age and sex in the Chinese population. Besides, after stratification by\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 status, almost all SNPs retain markedly relationship with LOAD in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 noncarriers. However, few loci retain correlation in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers. Furthermore, the area under the receiver operating characteristic curve prediction model for distinguishing LOAD patients from normal subjects were 0.614 for PRS and 0.689 for PRS and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      . In addition, meta-analysis including this study of East Asian populations confirmed that rs610932 and rs3851179 were dramatically related to the LOAD (OR = 0.85, 95% CI\u2009=\u20090.74-0.97; OR = 0.87, 95% CI\u2009=\u20090.83-0.91).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Despite genetic heterogeneity, there are still common loci among different races. PRS based on AD risk-associated SNPs may supplement\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      for better assessing individual risk for AD in Chinese. Besides, interactions between genes and gene environment affect the impact of risk allele on diverse populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251326283","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T16:46:21Z","timestamp":1742575581000},"page":"205-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validate association of gene loci and establish genetic risk prediction models for late-onset Alzheimer's disease in Chinese populations"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-1100","authenticated-orcid":false,"given":"Fangyu","family":"Li","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3616-2575","authenticated-orcid":false,"given":"Menghan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-0336","authenticated-orcid":false,"given":"Jianping","family":"Jia","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China"},{"name":"Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China"},{"name":"Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China"},{"name":"Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Global status report on the public health response to dementia","author":"World Health Organization","year":"2021","unstructured":"World Health Organization. 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