{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:27:54Z","timestamp":1777397274226,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Altered synaptic physiology clearly contributes to memory loss and other CNS symptoms in Alzheimer's disease. A new paper in this issue of the\n                    <jats:italic toggle=\"yes\">Journal of Alzheimer's Disease,<\/jats:italic>\n                    from Zhe Jin's group in Uppsala, Sweden, adds important new information to help us understand how. A powerful, yet largely uncharacterized form of neuronal inhibition\u2014GABA\n                    <jats:sub>A, slow<\/jats:sub>\n                    synaptic current\u2014was studied using whole-cell recordings in hippocampal brain slices from AD model mice (tg-APPSwe). The investigators found that GABA\n                    <jats:sub>A, slow<\/jats:sub>\n                    inhibition was significantly reduced in dentate granule neurons from aged AD mice, compared to both wild type and adult non-aged AD mice. This reduction would nicely explain the change in excitatory-inhibitory balance previously reported in this and other AD model animals, as well as impairments in pattern separation and theta-gamma cross-frequency coupling that are early manifestations of AD.\n                  <\/jats:p>","DOI":"10.1177\/13872877251328940","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:40:34Z","timestamp":1742553634000},"page":"375-377","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Reduced GABA\n                    <sub>A, slow<\/sub>\n                    synaptic inhibition in Alzheimer's disease"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-8954","authenticated-orcid":false,"given":"M Bruce","family":"MacIver","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Pearce","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90310-N"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00303.2021"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80907-1"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.10.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-8"},{"key":"e_1_3_4_7_2","first-page":"13145","article-title":"Brain aging and Alzheimer\u2019s disease, a perspective from non-human primates","volume":"16","author":"Isidro F","year":"2024","unstructured":"Isidro F. Brain aging and Alzheimer\u2019s disease, a perspective from non-human primates. Aging (Albany NY) 2024; 16: 13145\u201313171.","journal-title":"Aging (Albany NY)"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.11.012"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.774600"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251317608"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200527"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.01.005"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.021"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.02.014"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00790"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00101"},{"key":"e_1_3_4_17_2","first-page":"428","article-title":"Toward the identification of neurophysiological biomarkers for Alzheimer\u2019s disease in down syndrome: a potential role for cross-frequency phase-amplitude coupling analysis","volume":"14","author":"Victorino DB","year":"2023","unstructured":"Victorino DB, Faber J, Pinheiro DJLL, et al. Toward the identification of neurophysiological biomarkers for Alzheimer\u2019s disease in down syndrome: a potential role for cross-frequency phase-amplitude coupling analysis. Aging Dis 2023; 14: 428\u2013449.","journal-title":"Aging Dis"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02457-w"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2024.12.001"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000007178"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0315-15.2015"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13623"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413604"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877241289602"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251328940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251328940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251328940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:16Z","timestamp":1777371016000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251328940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/13872877251328940"],"URL":"https:\/\/doi.org\/10.1177\/13872877251328940","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}