{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:39Z","timestamp":1777397139218,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"crossref","award":["338182"],"award-info":[{"award-number":["338182"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"crossref","award":["339767"],"award-info":[{"award-number":["339767"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Strategic Neuroscience Funding of the University of Eastern Finland"},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-24-1284326-C"],"award-info":[{"award-number":["ADSF-24-1284326-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-24-1284326-C"],"award-info":[{"award-number":["ADSF-24-1284326-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-24-1284326-C"],"award-info":[{"award-number":["ADSF-24-1284326-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is a common disorder in aging populations. Alzheimer's disease (AD) is a significant comorbidity in iNPH patients, and the presence of AD pathology is associated with worse shunting outcomes. Cerebrospinal fluid (CSF) concentrations of AD-associated biomarkers in iNPH patients are universally reduced and the exact mechanism related to this is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim was to study the effects of ventricular volume on CSF AD-associated biomarker levels in iNPH patients, to determine whether a dilution effect occurs and to assess if brain AD pathology contributes to this effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 153 iNPH patients had lumbar CSF samples available for analysis, along with brain MRIs of sufficient quality. Automated image analysis software was used to determine the volume of different brain segments. Volumes normalized for age, sex and head size were used for analysis. Brain biopsy data on AD pathology was also available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>None of the intracerebral ventricular volumes correlated with CSF levels of AD-associated biomarkers, indicating no dilution effect was present in this context. However, in iNPH patients positive for amyloid-\u03b2 pathology in the biopsy, the volume of the fourth ventricle correlated inversely with all investigated biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Intracerebral ventricular volumes do not correlate with AD biomarker levels in CSF, arguing against a dilution effect. However, in patients with AD pathology, the volume of the fourth ventricle is inversely correlated with CSF T-Tau and P-Tau\n                      <jats:sub>181<\/jats:sub>\n                      levels, suggesting a complex relationship between brain AD pathology, CSF flow and CSF volume in iNPH patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251329081","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T20:16:05Z","timestamp":1743192965000},"page":"397-406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3871-5970","authenticated-orcid":false,"given":"Aleksi","family":"Vanninen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"},{"name":"Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1704-3406","authenticated-orcid":false,"given":"Lauri","family":"Erkkil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"},{"name":"Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Clinical Radiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-3912","authenticated-orcid":false,"given":"Tarja","family":"Kokkola","sequence":"additional","affiliation":[{"name":"Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-8565","authenticated-orcid":false,"given":"Tuomas","family":"Selander","sequence":"additional","affiliation":[{"name":"Science Service Center, Kuopio University Hospital (KUH) and School of Medicine, University of Eastern Finland (UEF), Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-0379","authenticated-orcid":false,"given":"Anne M","family":"Koivisto","sequence":"additional","affiliation":[{"name":"NeuroCenter, Kuopio University Hospital, Kuopio, Finland"},{"name":"Department of Neurosciences, University of Helsinki, Helsinki, Finland"},{"name":"Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-7537","authenticated-orcid":false,"given":"Merja","family":"Kokki","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Anaesthesia and Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-7152","authenticated-orcid":false,"given":"Tadeusz","family":"Musialowicz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-9084","authenticated-orcid":false,"given":"Anssi","family":"Lipponen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-4096","authenticated-orcid":false,"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-5440","authenticated-orcid":false,"given":"Juhana","family":"Hakum\u00e4ki","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Clinical Radiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[{"name":"Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Neurology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-327X","authenticated-orcid":false,"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kuopio University Hospital, Kuopio, Finland"},{"name":"Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-4687","authenticated-orcid":false,"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"},{"name":"Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168185.29659.C5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.st.2020-0292"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217705"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13710"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002225"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14671"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190334"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617722000868"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16049"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.021"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101544"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12816"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01314-6"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000916"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2fda"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00353-9"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180071"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0142-9"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111149"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220652"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.08.006"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-303849"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182563bd0"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.02.019"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.026"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-024-08810-4"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00521-3"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.5603\/pjnns.98212"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2023.111671"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-021-00251-6"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322572121"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzp059"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi2002482"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40742-0"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.11.059"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106035"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007505"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa179"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.10.003"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.02.022"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02454-z"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102804"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00318-y"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1051-z"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251329081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251329081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251329081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:16Z","timestamp":1777371016000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251329081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/13872877251329081"],"URL":"https:\/\/doi.org\/10.1177\/13872877251329081","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}