{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:46:26Z","timestamp":1788821186062,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100016003","name":"Istanbul \u00dcniversitesi-Cerrahpasa","doi-asserted-by":"publisher","award":["33638"],"award-info":[{"award-number":["33638"]}],"id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016003","name":"Istanbul \u00dcniversitesi-Cerrahpasa","doi-asserted-by":"publisher","award":["33479"],"award-info":[{"award-number":["33479"]}],"id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["22AG017 - APYOK2"],"award-info":[{"award-number":["22AG017 - APYOK2"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016003","name":"Istanbul \u00dcniversitesi-Cerrahpasa","doi-asserted-by":"publisher","award":["37292"],"award-info":[{"award-number":["37292"]}],"id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The data that we gathered from a protein-protein interaction (PPI) prediction tool, FpClass, and a limited number of studies indicated that the chaperones HSP90AA1, HSPA4, STUB1\/CHIP might interact with amyloid-\u03b2 (A\u03b2) and\/or tau and could subsequently be co-released into the cerebrospinal fluid (CSF). Therefore, we investigated CSF levels of HSP90AA1, HSPA4, and STUB1\/CHIP in Alzheimer's disease (AD), Non-AD mild cognitive impairment (Non-AD MCI), and frontotemporal dementia (FTD) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CSF levels of HSP90AA1, HSPA4, STUB\/CHIP, and core AD biomarkers were determined by ELISA in AD (n\u2009=\u200990), Non-AD MCI (n\u2009=\u200927), FTD (n\u2009=\u200915), and subjective cognitive impairment (SCI) (n\u2009=\u200920) subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HSP90AA1 levels were significantly higher in AD cases compared to the SCI subjects. The CSF levels of STUB1\/CHIP were significantly lower in AD, Non-AD MCI and FTD cases compared to the SCI subjects. STUB1\/CHIP levels of FTD cases were significantly lower than all other groups. HSPA4 levels was correlated with core AD biomarkers (A\u03b2 1\u201342, p-Tau, t-Tau) regardless of disease. Non-\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carrier FTD cases also had significantly lower STUB1\/CHIP levels than other groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The STUB1\/CHIP holds promise as a potential biomarker for distinguishing between SCI subjects, AD, and FTD. Furthermore,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      might serve as an additional discriminatory factor that might be integrated with this chaperone for enhanced discrimination.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251329540","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T16:49:18Z","timestamp":1742575758000},"page":"481-493","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1\/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-0250","authenticated-orcid":false,"given":"Pelin","family":"Sordu","sequence":"first","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-5437","authenticated-orcid":false,"given":"Merve","family":"Alayl\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-2329","authenticated-orcid":false,"given":"Bedia","family":"Samanc\u0131","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6845-1495","authenticated-orcid":false,"given":"Ersel","family":"Bulu","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-2111","authenticated-orcid":false,"given":"Zeynep Ece Kaya","family":"G\u00fcle\u00e7","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-0856","authenticated-orcid":false,"given":"Ba\u015far","family":"Bilgi\u00e7","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u015fmet Ayhan","family":"Hana\u011fas\u0131","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2908-8475","authenticated-orcid":false,"given":"\u0130brahim Hakan","family":"G\u00fcrvit","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-1746","authenticated-orcid":false,"given":"Turgut","family":"Ulutin","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-6674","authenticated-orcid":false,"given":"Erdin\u00e7","family":"Dursun","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-2111","authenticated-orcid":false,"given":"Duygu","family":"Gezen-Ak","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61066-7"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.06.005"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2016.11.007"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109322"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-018-1223-y"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188605"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.4274\/npa.y7089"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00512"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-018-8498-6"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00245"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00268"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12816"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.04.030"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986611794475093"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/495091"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/618127"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2017.00099"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6680"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.02.004"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1844-y"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-007-0029-7"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226021"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.014"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03295-4"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-018-1174-3"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601603200"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3178"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01644143"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988716640373"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsp004"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180825"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130497"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12104"},{"key":"e_1_3_5_39_2","article-title":"Heat shock protein 90: biological functions, diseases, and therapeutic targets","volume":"5","author":"Wei H","year":"2024","unstructured":"Wei H, Zhang Y, Jia Y, et al. Heat shock protein 90: biological functions, diseases, and therapeutic targets. MedComm (2020) 2024; 5: e470.","journal-title":"MedComm (2020)"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03272.x"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9063-4"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh083"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124332"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm030"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12335"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8246-0"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006550"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64189-2.00005-6"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081884"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.05.001"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-019-00595-0"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115870"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10348-x"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.878236"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20204976"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00093"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.013"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.02.017"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-016-2647-1"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251329540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251329540","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251329540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:18Z","timestamp":1777371018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251329540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/13872877251329540"],"URL":"https:\/\/doi.org\/10.1177\/13872877251329540","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}