{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:27:51Z","timestamp":1777397271459,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The hippocampus plays a central role in cognition and hippocampal atrophy is a key hallmark of Alzheimer's disease. Evidence has suggested associations between hippocampal subfield volumes and specific cognitive domains and dementia risk. However, to our knowledge, no study has examined the role of hippocampal subfield volumes in cognitive decline across different domains over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated associations between hippocampal subfield volumes and changes in cognitive domains together with incident dementia in a memory clinic cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Associations between hippocampal subfield volumes and cognitive decline over three years (\n                      <jats:italic toggle=\"yes\">n\u2009<\/jats:italic>\n                      =\u2009443) were analyzed using generalized estimating equations, and associations with incident dementia (\n                      <jats:italic toggle=\"yes\">n\u2009<\/jats:italic>\n                      =\u2009283) using multiple logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, all hippocampal subfield volumes were associated with diagnosis of dementia, while the CA4-dentate gyrus, molecular layer, subicular complex, and fimbria volumes were associated with diagnosis of CIND. Over three years, all subfields except the hippocampal fissure were associated with memory. Decreased molecular layer (OR:2.26, 95%CI:1.50;3.50) size was associated with increased risk of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that hippocampal atrophy of the cornu ammonis, CA4-dentate gyrus, and molecular layer may first manifest with cognitive impairment in memory before other subfields of the hippocampus, and that molecular layer volume may be an early biomarker of dementia. Further research demonstrating the biological role of hippocampal subfields in specific cognitive domains is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251329574","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:37:41Z","timestamp":1743752261000},"page":"538-549","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of hippocampal subfield volumes on cognitive decline and incident dementia in a memory clinic cohort"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-9531","authenticated-orcid":false,"given":"Mervyn JR","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, University Surgical Centre, National University Health System, Singapore"},{"name":"Memory Ageing and Cognition Center, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-9345","authenticated-orcid":false,"given":"Jaclyn","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University Surgical Centre, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-593X","authenticated-orcid":false,"given":"Caroline","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Ying","family":"Tan","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-6362","authenticated-orcid":false,"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-9225","authenticated-orcid":false,"given":"Christopher","family":"Chen","sequence":"additional","affiliation":[{"name":"Memory Ageing and Cognition Center, National University Health System, Singapore"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-5635","authenticated-orcid":false,"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[{"name":"Memory Ageing and Cognition Center, National University Health System, Singapore"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.032"},{"key":"e_1_3_5_3_2","first-page":"298","article-title":"Cognitive aging and the hippocampus in older adults","volume":"8","author":"O'Shea A","year":"2016","unstructured":"O'Shea A, Cohen RA, Porges EC, et al. 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