{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:28:10Z","timestamp":1777397290658,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2018-28 and CVON 2012-06"],"award-info":[{"award-number":["2018-28 and CVON 2012-06"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Life-MI","award":["in kind co-financing for tracer production of amyloid PET-scans"],"award-info":[{"award-number":["in kind co-financing for tracer production of amyloid PET-scans"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carotid occlusive disease is a risk factor for cognitive decline. A possible underlying etiology is that hemodynamic impairment results in decreased cerebral perfusion, exacerbated amyloid-\u03b2 accumulation (A\u03b2) and poorer cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to determine whether patients with unilateral internal carotid artery (ICA) occlusion have less cerebral perfusion and more A\u03b2 in the ipsilateral than in the contralateral hemisphere, and whether perfusion and A\u03b2 are associated with cognitive functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 20 patients (age 67.2\u2009\u00b1\u20097.0 years, 8 females, MMSE 29 [27\u201329]) with unilateral ICA occlusion, which underwent neuropsychological assessment and dynamic\n                      <jats:sup>18<\/jats:sup>\n                      F-Florbetaben positron emission tomography (PET). Global and regional relative perfusion (R\n                      <jats:sub>1<\/jats:sub>\n                      ) and binding potential (BP\n                      <jats:sub>ND<\/jats:sub>\n                      ) were obtained from the PET-images using a simplified reference tissue model. We performed Wilcoxon signed-rank tests to examine differences between hemispheres within subjects and linear regression to investigate associations with cognitive functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median global R\n                      <jats:sub>1<\/jats:sub>\n                      was 0.911 (0.883\u20130.950) and global BP\n                      <jats:sub>ND<\/jats:sub>\n                      was 0.172 (0.129\u20130.187). R\n                      <jats:sub>1<\/jats:sub>\n                      was lower in the hemisphere ipsilateral to the ICA occlusion than in the contralateral hemisphere (0.899 [0.876\u20130.921] versus 0.935 [0.889\u20130.970]). BP\n                      <jats:sub>ND<\/jats:sub>\n                      did not differ significantly between hemispheres (ipsilateral 0.172 [0.124\u20130.181] versus contralateral 0.168 [0.137\u20130.191]). Neither cerebral perfusion nor A\u03b2 burden were associated with cognitive functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with unilateral ICA occlusion did not have more A\u03b2 in the ipsilateral hemisphere than in the contralateral hemisphere despite ipsilateral hypoperfusion. Perfusion and A\u03b2 were unrelated to cognitive functioning. This indicates that cognitive impairment in patients with ICA occlusion is not due to exacerbated A\u03b2 accumulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251329593","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T03:48:01Z","timestamp":1744861681000},"page":"519-530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-7126","authenticated-orcid":false,"given":"Naomi LP","family":"Starmans","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E","family":"Leeuwis","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands"},{"name":"Department of Medical Psychology, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-8532","authenticated-orcid":false,"given":"Edwin","family":"Bennink","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan L","family":"Meyer Viol","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-7160","authenticated-orcid":false,"given":"Sandeep SV","family":"Golla","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-9587","authenticated-orcid":false,"given":"Jan Willem","family":"Dankbaar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-9263","authenticated-orcid":false,"given":"Esther E","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-2496","authenticated-orcid":false,"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-6630","authenticated-orcid":false,"given":"L Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-6224","authenticated-orcid":false,"given":"Wiesje M","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands"},{"name":"Department of Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-2833","authenticated-orcid":false,"given":"Nelleke","family":"Tolboom","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Heart-Brain Connection Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.09.006"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17732884"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf047"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1214"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.204"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0192-1"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101762"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00115"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.2265"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.04.014"},{"key":"e_1_3_5_12_2","first-page":"316","article-title":"Reduction in amyloid \u03b2 deposition on 18F-florbetapir positron emission tomography with correction of cerebral hypoperfusion after endarterectomy for carotid stenosis","volume":"9","author":"Ogasawara K","year":"2019","unstructured":"Ogasawara K, Fujiwara S, Chida K, et al. 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