{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:56Z","timestamp":1787019176329,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010229","name":"Natural Science Foundation of Tianjin Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["2023KJ060"],"award-info":[{"award-number":["2023KJ060"]}],"id":[{"id":"10.13039\/501100010229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019066","name":"Tianjin Municipal Transportation Commission Science and Technology Development Plan Project","doi-asserted-by":"publisher","award":["22ZYCGSY00840"],"award-info":[{"award-number":["22ZYCGSY00840"]}],"id":[{"id":"10.13039\/501100019066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["TJWJ2023QN060"],"award-info":[{"award-number":["TJWJ2023QN060"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013084","name":"Program for Innovation Team Building at Institutions of Higher Education in Chongqing Municipality","doi-asserted-by":"publisher","award":["2022L250"],"award-info":[{"award-number":["2022L250"]}],"id":[{"id":"10.13039\/501100013084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015306","name":"Fund for Shanxi Key Subjects Construction","doi-asserted-by":"publisher","award":["TJYXZDXK-052B"],"award-info":[{"award-number":["TJYXZDXK-052B"]}],"id":[{"id":"10.13039\/501100015306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171182"],"award-info":[{"award-number":["82171182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Scientific Research Projects in Key Areas of Traditional Chinese Medicine","award":["2025017"],"award-info":[{"award-number":["2025017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia with Lewy bodies (DLB) is the second most common dementia after Alzheimer's disease. Currently, no specific therapeutic agents are available for DLB. However, evidence of cholinergic deficits suggests that enhancing central cholinergic function may be a viable therapeutic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess cognitive changes in DLB patients treated with cholinesterase inhibitors (ChEIs) in a real-world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study in a prospective database analyzed data from three dementia clinics between May 2012 and December 2022. Patients with DLB were divided into two groups: those treated with ChEIs and those untreated. Differences in changes in multiple cognitive-related scales between the two groups were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 204 DLB patients, with 133 (65.2%) in the ChEIs group and 71 (34.8%) in the non-ChEIs group. Initial demographic and clinical characteristics were similar between groups. Over time, patients in the ChEIs group showed significantly higher scores on the Mini-Mental State Examination and the Montreal Cognitive Assessment compared to the non-ChEIs group, indicating improved cognitive function. No significant differences were observed in activities of daily living scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ChEIs improved cognitive symptoms in DLB patients in the \u201creal world\u201d study. These findings are consistent with those from a previous small-sample randomized controlled trial. Longitudinal data indicate sustained benefits with continuous ChEIs use in three years. Overall, ChEIs show substantial potential for improving cognitive symptoms in DLB patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251330902","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T01:16:42Z","timestamp":1745284602000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of cholinesterase inhibitors treatment in dementia with Lewy bodies: A 3-year follow-up \u2018real world\u2019 study"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9195-1698","authenticated-orcid":false,"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and neurodegenerative diseases, Tianjin dementia institute, Tianjin Huanhu Hospital, Tianjin, China"},{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9305-4560","authenticated-orcid":false,"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China"},{"name":"Department of Neurology, Linfen Central Hospital, Linfen, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-2834","authenticated-orcid":false,"given":"Jinghuan","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and neurodegenerative diseases, Tianjin dementia institute, Tianjin Huanhu Hospital, Tianjin, China"},{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and neurodegenerative diseases, Tianjin dementia institute, Tianjin Huanhu Hospital, Tianjin, China"},{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-6996","authenticated-orcid":false,"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and neurodegenerative diseases, Tianjin dementia institute, Tianjin Huanhu Hospital, Tianjin, China"},{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 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