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However, correlations between OCT\/OCT-A and neurodegeneration metrics remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We performed a systematic review of OCT\/OCT-A and structural brain imaging using MRI across various neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Medline, Embase, and various other databases from January to June 2023 using keywords regarding neurodegenerative conditions and OCT\/OCT-A. Out of 2962 citations. 93 articles were reviewed, and 28 met our inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Layer-or-region-specific retinal metrics were the most promising for non-vascular neurodegeneration, while vascular retinal parameters had the unique capacity to reflect vascular lesions. Both types of biomarkers correlated with global brain atrophy. Microstructural brain alterations best correlated with layer-specific thinning of retina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A better understanding of associations between retinal and brain lesions could eventually lead to the clinical application of retinal biomarkers for the early diagnosis of neurodegenerative conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251331231","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:29:06Z","timestamp":1745206146000},"page":"697-713","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5868-2310","authenticated-orcid":false,"given":"Fei","family":"Wu","sequence":"first","affiliation":[{"name":"Research Chair on Primary Progressive Aphasia - Fondation de la famille Lemaire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Clinique Interdisciplinaire de M\u00e9moire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-2209","authenticated-orcid":false,"given":"Caroline","family":"Dallaire-Th\u00e9roux","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Division of Neuroscience, H\u00f4pital de l\u2019Enfant-J\u00e9sus, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6231-1010","authenticated-orcid":false,"given":"\u00c9lodie","family":"Michaud","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-7420","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Biblioth\u00e8que de l\u2019Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-9782","authenticated-orcid":false,"given":"Monica","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Research Chair on Primary Progressive Aphasia - Fondation de la famille Lemaire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-1259","authenticated-orcid":false,"given":"Jean-Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2013-5538","authenticated-orcid":false,"given":"Ali","family":"Dirani","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Centre universitaire d'ophtalmologie, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-490X","authenticated-orcid":false,"given":"Robert Jr","family":"Laforce","sequence":"additional","affiliation":[{"name":"Research Chair on Primary Progressive Aphasia - Fondation de la famille Lemaire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Clinique Interdisciplinaire de M\u00e9moire, Centre Hospitalier Universitaire de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"},{"name":"Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Major neurocognitive disorder (dementia). 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