{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:56:51Z","timestamp":1781931411678,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIH K23(AG066931)."],"award-info":[{"award-number":["NIH K23(AG066931)."]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG070937"],"award-info":[{"award-number":["R01 AG070937"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR\u2009=\u20091.94, 95% CI 1.20\u20133.20) greater odds of AD biomarker positivity for tTau\/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    and 108% (OR\u2009=\u20092.08, 95% Cl, 1.27\u20133.46) for pTau181\/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    . Our results suggest that higher arterial stiffness is associated with AD CSF biomarker positivity.\n                  <\/jats:p>","DOI":"10.1177\/13872877251331235","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:29:36Z","timestamp":1745206176000},"page":"729-735","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0428-7554","authenticated-orcid":false,"given":"Hyena","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-1352","authenticated-orcid":false,"given":"Ambar","family":"Kulshreshtha","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA"},{"name":"Department of Family and Preventive Medicine, Emory School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-8323","authenticated-orcid":false,"given":"Alvaro","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-3617","authenticated-orcid":false,"given":"Felicia C","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory School of Medicine, Atlanta, GA, USA"},{"name":"Emory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0604-2944","authenticated-orcid":false,"given":"Erik CB","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory School of Medicine, Atlanta, GA, USA"},{"name":"Emory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E","family":"Gold","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-679X","authenticated-orcid":false,"given":"Arshed A","family":"Quyyumi","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-620X","authenticated-orcid":false,"given":"James J","family":"Lah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory School of Medicine, Atlanta, GA, USA"},{"name":"Emory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.870517"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionps.2023.100063"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.10.010"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2094"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221187"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.053883"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40501-8"},{"key":"e_1_3_4_15_2","first-page":"1236","article-title":"Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients","volume":"37","author":"Laurent S","year":"2001","unstructured":"Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 1979 2001; 37: 1236\u20131241.","journal-title":"Hypertension 1979"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014621"},{"key":"e_1_3_4_17_2","first-page":"710","article-title":"Association of aortic stiffness and pressure pulsatility With global amyloid-\u03b2 and regional tau burden among Framingham Heart Study participants without dementia","volume":"79","author":"Cooper LL","year":"2022","unstructured":"Cooper LL, O'Donnell A, Beiser AS, et al. Association of aortic stiffness and pressure pulsatility With global amyloid-\u03b2 and regional tau burden among Framingham Heart Study participants without dementia. JAMA 2022; 79: 710\u2013719.","journal-title":"JAMA"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1065335"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06277"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501856"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501856"},{"key":"e_1_3_4_22_2","unstructured":"Roche. FDA grants Breakthrough Device Designation for Roche\u2019s Elecsys Cerebrospinal Fluid (CSF) Assays to Support the Improved Diagnosis of Alzheimer\u2019s disease https:\/\/www.roche.com\/media\/releases\/med-cor-2018-07-20 (2018)."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.09.009"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834fa8b0"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-34"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02359-0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005477"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2022.03.009"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2022-0516"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54204-z"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly157"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.10.008"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11443"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.02.038"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005259"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25380"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.10.018"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.126342"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093674"},{"key":"e_1_3_4_40_2","unstructured":"Average years of schooling. Our World in Data https:\/\/ourworldindata.org\/grapher\/mean-years-of-schooling-long-run (accessed 23 April 2024)."},{"key":"e_1_3_4_41_2","article-title":"CSF Tau and the CSF tau\/ABeta ratio for the diagnosis of Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"3","author":"Ritchie C","year":"2017","unstructured":"Ritchie C, Smailagica N, Noel-Storr AH, et al. CSF Tau and the CSF tau\/ABeta ratio for the diagnosis of Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2017; 3: CD010803.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70501-4"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.41"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-090249"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251331235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251331235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251331235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:21Z","timestamp":1777371021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251331235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/13872877251331235"],"URL":"https:\/\/doi.org\/10.1177\/13872877251331235","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}