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Despite its potential, the implications of repeated LIFU neuromodulation in AD patients remain to be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot study evaluated the safety and potential to improve cognition and functional connectivity following repeated LIFU treatment in AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten early-stage AD patients underwent six sessions of neuronavigation-guided LIFU targeting the left dorsolateral prefrontal cortex (DLPFC) within 2\u20133 weeks, alongside ongoing standard pharmacotherapy. Neuropsychological assessments and resting-state functional magnetic resonance imaging were performed at baseline and eight weeks post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Memory performance (p\u2009=\u20090.02) and functional connectivity between the left DLPFC and both the left perirhinal cortex and left dorsomedial prefrontal cortex (corrected p\u2009&lt;\u20090.05) significantly improved from baseline. Additionally, enhancements in memory performance were positively correlated with increases in functional connectivity of the left DLPFC with the left perirhinal cortex (Kendall's tau\u2009=\u20090.56, p\u2009=\u20090.03). No adverse events were reported during the LIFU treatments or at the subsequent follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LIFU may have the therapeutic potential to enhance both brain network connectivity and memory functions in AD patients. Our results provide a basis for further research, including randomized sham-controlled trials and optimization of stimulation protocols, on LIFU as a supplementary or alternative treatment option for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Clinical Research Information Service, KCT0008169, Registered on 10 February 2023<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251333614","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:51:20Z","timestamp":1745419880000},"page":"955-965","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Repeated neuromodulation with low-intensity focused ultrasound in patients with Alzheimer's disease"],"prefix":"10.1177","volume":"105","author":[{"given":"Hyeonseok","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Radiology, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea"},{"name":"Department of Neurology, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5237-4280","authenticated-orcid":false,"given":"Doyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-8578","authenticated-orcid":false,"given":"Seunghee","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Incheon St 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