{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:55:58Z","timestamp":1791197758682,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) is a form of cerebral small vessel disease (SVD) associated with Alzheimer's disease, intracerebral hemorrhage, and cognitive decline. Despite its clinical significance, no reliable serum biomarker exists for early diagnosis or monitoring of disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study hypothesizes that \u03b11-acid glycoprotein (\u03b11-AGP) and other serum biomarkers can aid CAA diagnosis and assessment using gel-based mass spectrometry. A comparative analysis was performed to investigate associations between serum biomarkers and radiological scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum proteins from individuals with probable or possible CAA (n\u2009=\u200910), classified using the modified Boston criteria, and age-matched controls (n\u2009=\u200910) were analyzed via two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption\/ionization time-of-flight tandem mass spectrometry (MALDI-TOF\/TOF-MS). Candidate proteins were validated using enzyme-linked immunosorbent assay (ELISA). Outcome measures included biomarker diagnostic accuracy, assessed by receiver operating characteristic (ROC) curve analysis, and correlations between \u03b11-AGP levels and CAA-SVD scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four proteins\u2014hemopexin, complement C3, complement C9, and \u03b11-AGP\u2014were significantly elevated, while apolipoprotein A-1 was reduced in the CAA group. ELISA confirmed higher \u03b11-AGP levels in individuals with CAA (p\u2009&lt;\u20090.0001). ROC analysis demonstrated that \u03b11-AGP could indicate the presence of CAA with a sensitivity and specificity of 1.00 (95%CI: 1.000, 1.000). Additionally, \u03b11-AGP levels correlated with the CAA-SVD score (R\u00b2\u2009=\u20090.783).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\u03b11-AGP may serve as a novel serum biomarker for CAA. Larger cohorts and external validation are required to substantiate these findings and determine their clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251333802","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:03:34Z","timestamp":1745319814000},"page":"1007-1016","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Alpha-1-acid glycoprotein as a potential serum biomarker for cerebral amyloid angiopathy"],"prefix":"10.1177","volume":"105","author":[{"given":"Akisato","family":"Nishigaki","sequence":"first","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, 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