{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:38:35Z","timestamp":1792096715862,"version":"4.4.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific and Technological Research and Development Plan of Qinhuangdao","award":["202301A142"],"award-info":[{"award-number":["202301A142"]}]},{"name":"the Science and Technology Plan Project of Liaoning Province","award":["2022JH2\/20200063"],"award-info":[{"award-number":["2022JH2\/20200063"]}]},{"name":"Scientist Partner Project of China Medical 24 University-Shenyang Branch of Chinese Academy of Sciences","award":["HZHB2022017"],"award-info":[{"award-number":["HZHB2022017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The involvement of microglia is likely to be pivotal in the pathogenesis of Alzheimer's disease (AD) by modulating the deposition of amyloid-\u03b2 (A\u03b2) plaques. The deletion of Dedicator of cytokinesis 8 (DOCK8) has a protective effect in mouse with neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the underlying mechanism of DOCK8 in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In present study, we first the detected the expression of DOCK8 in the hippocampal tissue of APP\/PS1 mice. Then, the expression of DOCK8 was knocked down in the hippocampal tissue of APP\/PS1 mice, and the effects of DOCK8 down-regulation on cognitive function, the microglia migration around A\u03b2 plaques, and the cell division cycle 42 (Cdc42)\/p38 mitogen-activated protein kinase (MAPK) signaling pathway were detected. Next, the effects of DOCK8 knockdown on A\u03b2-induced migration and activation of BV-2 cells as well as the MAPK signaling pathway were detected. Finally, the transcriptional regulation of DOCK by transcription factor 3 (ATF3) was detected by a dual luciferase reporter assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DOCK8 expression exerts a significant upregulation in the hippocampus of APP\/PS1 mice. However, following the DOCK8 knockdown, there was a significant recovery in the results of the behavioral tests and a notable reduction in microglial expression. Moreover, the high expression of DOCK8 mediated by ATF3 successfully triggered the Cdc42\/p38 MAPK signaling pathway, thereby enhancing the migration and recruitment of microglia towards senile plaques, accelerating the production of A\u03b2 plaques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ATF3-mediated high expression of DOCK8 accelerates the production of A\u03b2 plaques, and participates in the pathogenesis of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251336266","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:53:59Z","timestamp":1745420039000},"page":"1385-1399","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel finding relates to the involvement of ATF3\/DOCK8 in Alzheimer's disease pathogenesis"],"prefix":"10.1177","volume":"105","author":[{"given":"Wenqiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People's Republic of China"},{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifa","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurointerventional Department, Huludao Central Hospital, Huludao, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"},{"name":"School of Pharmacy, China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"},{"name":"Science Experiment Center, China Medical University, Shenyang, Liaoning, People's Republic of 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