{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:08:13Z","timestamp":1777957693314,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Research Funding for Longevity Sciences from the National Center for Geriatrics and Gerontology, Japan","award":["joint research fund"],"award-info":[{"award-number":["joint research fund"]}]},{"DOI":"10.13039\/100015377","name":"Nihon Medi-Physics Co., Ltd.","doi-asserted-by":"crossref","award":["joint research fund"],"award-info":[{"award-number":["joint research fund"]}],"id":[{"id":"10.13039\/100015377","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Background<\/jats:title>\n \n 18<\/jats:sup>\n F-fluoro-2-deoxy-2-D-glucose positron emission tomography (\n 18<\/jats:sup>\n F-FDG PET) is a biomarker of neuronal injury, according to the revised National Institute on Aging-Alzheimer's Association criteria.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This multicenter prospective cohort study aimed to evaluate the value of\n 18<\/jats:sup>\n F-FDG PET for differential diagnosis of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) in comparison with phosphorylated tau protein (p-tau181) in cerebrospinal fluid (CSF).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In total, 138 patients (AD, 119; FTLD, 19) from 11 participating institutions underwent clinical and neuropsychological examinations, magnetic resonance imaging (MRI), CSF examination, and\n 18<\/jats:sup>\n F-FDG PET at baseline. The cases were visually classified into predefined dementia patterns using\n 18<\/jats:sup>\n F-FDG PET by three experts. A region-of-interest (ROI)-based automated analysis of\n 18<\/jats:sup>\n F-FDG PET was also performed. The participants were followed up for 12 months, and the clinical diagnosis of dementia was re-evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The sensitivity, specificity, and accuracy of the visual reading of\n 18<\/jats:sup>\n F-FDG PET for differentiating AD from FTLD were 94%, 78%, and 92%, respectively. In contrast, those of p-tau181 in CSF were 62%, 79%, and 65%, respectively. The sensitivity, the primary endpoint, was 32% higher for\n 18<\/jats:sup>\n F-FDG PET than for p-tau181 in CSF. Additionally, the accuracy, the secondary endpoint, was 27% higher for\n 18<\/jats:sup>\n F-FDG PET than for p-tau181 in CSF. In addition to the visual reading of\n 18<\/jats:sup>\n F-FDG PET, the ROI-based automated analysis showed sensitivity, specificity, and accuracy of 81%, 79%, and 81%, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study showed that the diagnostic performance of\n 18<\/jats:sup>\n F-FDG PET in differential diagnosis of AD and FTLD was higher than that of p-tau181 in CSF.\n <\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n UMIN-CTR (UMIN 000016427,\n https:\/\/www.umin.ac.jp\/ctr\/<\/jats:ext-link>\n ) and Japan Registry of Clinical Trials (jRCTs041180098,\n https:\/\/jrct.mhlw.go.jp\/<\/jats:ext-link>\n )\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13872877251338691","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:48:52Z","timestamp":1746496132000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["18<\/sup>\n F-FDG PET for the differential diagnosis of Alzheimer's disease and frontotemporal lobar degeneration: A multicenter prospective study in Japan"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-7045","authenticated-orcid":false,"given":"Kengo","family":"Ito","sequence":"first","affiliation":[{"name":"National Hospital for Geriatric Medicine, National Centre for Geriatrics and Gerontology, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Washimi","sequence":"additional","affiliation":[{"name":"National Hospital for Geriatric Medicine, National Centre for Geriatrics and Gerontology, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-4333","authenticated-orcid":false,"given":"Takashi","family":"Kato","sequence":"additional","affiliation":[{"name":"National Hospital for Geriatric Medicine, National Centre for Geriatrics and Gerontology, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"National Hospital for Geriatric Medicine, National Centre for Geriatrics and Gerontology, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuomi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chigusa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Hospital Organization, Hiroshima-Nishi Medical Center, Otake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Kutoku","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Team for Neuroimaging Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Kitayama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Okayama Kyokuto Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumasa","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 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