{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:28:58Z","timestamp":1777397338623,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Absalon Foundation of May 1st 1978"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deposition of amyloid-\u03b2 and tau are key pathological events in Alzheimer's disease and may be assessed by cerebrospinal fluid (CSF) biomarkers. It remains uncertain whether patients who display abnormal phosphorylated tau in isolation differ from patients with other biomarker profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective was to investigate differences in demographics, comorbidities, and cognitive performance in amyloid-\u03b2 negative phosphorylated tau positive patients. Further, the aim was also to investigate the relationship between cognitive function and phosphorylated tau level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1049 consecutive patients from the Copenhagen Memory Clinic Cohort from 2018 to August 2022 were included and divided into four groups based on the CSF biomarkers amyloid-\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      (A) and phosphorylated tau (T). Data on co-morbidities, abuse, and neuropsychological tests were recorded, and retrospective data analyses were performed across all groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2.8% participants had an A\u2013T+ biomarker profile and were younger (Mean: 65.1 years, SD: 14.2), comprised of more men (65.5%) than the A\u2009+\u2009T\u2013 group and exhibited both more psychiatric illness (p\u2009=\u20090.027) and alcohol and\/or drug abuse (p\u2009=\u20090.004) than the A\u2009+\u2009T+ group. The A\u2013T+ group performed better on both Addenbrooke's Cognitive Examination (p\u2009=\u20090.002) and Mini-Mental State Examination (p\u2009=\u20090.001) as well as immediate (p\u2009=\u20090.026) and delayed recall (p\u2009=\u20090.009) compared to the A\u2009+\u2009T+ group but showed no difference compared to the A\u2013T\u2013 group on all cognitive scores. Further, higher p-tau levels were associated with worse cognitive performance although effects were small.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings indicate that patients with the A\u2013T+ biomarker profile have different clinical characteristic that may indicate a non-neurodegenerative background.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251339679","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:56:38Z","timestamp":1750820198000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolated elevation of 181p-tau in the cerebrospinal fluid is associated with distinct clinical features: Findings from a Danish memory clinic cohort"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7623-0776","authenticated-orcid":false,"given":"Laura Storm N\u00e6sborg","family":"Andersen","sequence":"first","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-162X","authenticated-orcid":false,"given":"Anja Hviid","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-1061","authenticated-orcid":false,"given":"Asmus","family":"Vogel","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-8773","authenticated-orcid":false,"given":"Oskar Hoffmann","family":"McWilliam","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-4911","authenticated-orcid":false,"given":"Steen Gregers","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-4417","authenticated-orcid":false,"given":"Kristian Steen","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006247"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00817-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008361"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.251"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009724"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2024.60.1.51"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac297"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.2338"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1349-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.01.007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000434309.85312.19"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201506"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2023-0191"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.01.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly132"},{"key":"e_1_3_3_21_2","article-title":"Disease 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Disease trajectories in elders with suspected non-Alzheimer\u2019s pathophysiology and its comparison with Alzheimer\u2019s disease pathophysiology: A longitudinal study. Res Sq 2023. DOI: https:\/\/doi.org\/10.21203\/rs.3.rs-2744271\/v1. 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