{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:28:35Z","timestamp":1777397315796,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers. MRI, being non-invasive, accessible, and cost-effective, holds promise as a biomarker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the utility of MRI-based automated brain volumetry in classifying cognitive impairment severity\u2014cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia\u2014as well as ATN profiles, independently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 394 subjects from the Alzheimer's Disease Neuroimaging Initiative. First, we assessed how well MRI volumetry stratifies cognitive stages. Next, we tested its ability to distinguish A\u2009+\u2009T\u2009+\u2009N+ from A-T-N- individuals while classifying clinical stages. Finally, we evaluated its predictive power for cognitive severity in A\u2009+\u2009T+ and A-T- subgroups, irrespective of neurodegeneration (N), to examine the added value of volumetry across AT profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MRI volumetry showed comparable performance to established biomarkers in identifying CU, MCI, and dementia, and offered complementary value when combined with phosphorylated tau. Hippocampal and temporal gray matter volumes distinguished A\u2009+\u2009T\u2009+\u2009N+ from A-T-N- classes with accuracies of 0.81 and 0.78, respectively. In A\u2009+\u2009T+ versus A-T- comparisons, the highest classification performance for cognitive severity was observed in the A-T- group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MRI-based brain volumetry can effectively classify cognitive stages and distinguish biological subtypes in AD. It is a promising tool for clinical staging and predicting impairment severity, especially when used alongside phosphorylated tau.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251339840","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:19:31Z","timestamp":1747106371000},"page":"245-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-2475","authenticated-orcid":false,"given":"Ilaria","family":"Ricchi","sequence":"first","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland"},{"name":"MIPlab, Neuro-X Institute, \u00c9cole Polytechnique F\u00e9d\u00e9ral de Lausanne (EPFL), Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-1653","authenticated-orcid":false,"given":"Alessandra","family":"Griffa","sequence":"additional","affiliation":[{"name":"MIPlab, Neuro-X Institute, \u00c9cole Polytechnique F\u00e9d\u00e9ral de Lausanne (EPFL), Geneva, Switzerland"},{"name":"Department of Clinical Neurosciences, Leenaards Memory Centre, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-9850","authenticated-orcid":false,"given":"Ricardo","family":"Corredor-Jerez","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland"},{"name":"Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"LTS5, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-5634","authenticated-orcid":false,"given":"Jonas","family":"Richiardi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-6175","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"D\u00e9monet","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Leenaards Memory Centre, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Allali","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Leenaards Memory Centre, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-2854","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Mar\u00e9chal","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland"},{"name":"Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"LTS5, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-8421","authenticated-orcid":false,"given":"Olivier","family":"Rouaud","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Leenaards Memory Centre, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"For the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000912"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7437"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23671"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.251"},{"key":"e_1_3_4_7_2","first-page":"59","article-title":"Suspected non-Alzheimer\u2019s disease pathophysiology (SNAP) and its pathological backgrounds in the diagnosis of preclinical and clinical Alzheimer\u2019s disease","volume":"70","author":"Yamada M","year":"2018","unstructured":"Yamada M. Suspected non-Alzheimer\u2019s disease pathophysiology (SNAP) and its pathological backgrounds in the diagnosis of preclinical and clinical Alzheimer\u2019s disease. Brain Nerve 2018; 70: 59\u201371.","journal-title":"Brain Nerve"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-2021-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0512-1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0837-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_3_4_12_2","first-page":"22","article-title":"An overview of the first 8 ADNI CSF batch analyses","volume":"14","author":"Shaw LM","year":"2018","unstructured":"Shaw LM, Figurski M, Waligorska T, et al. An overview of the first 8 ADNI CSF batch analyses. Alzheimers Dement 2018; 14: 22.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00928-y"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm319"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.013"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.050"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.11.001"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0755-1"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330619"},{"key":"e_1_3_4_23_2","unstructured":"ADNI | Question https:\/\/adni.loni.usc.edu\/support\/experts-knowledge-base\/question\/?QID=1399 (accessed 17 June 2022)."},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12491"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022193"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.2642"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2020.63"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01263-2"},{"issue":"2","key":"e_1_3_4_33_2","article-title":"Pathology of clinical and preclinical Alzheimer\u2019s disease","volume":"263","author":"Thal DR","year":"2013","unstructured":"Thal DR, von Arnim C, Griffin WST, et al. Pathology of clinical and preclinical Alzheimer\u2019s disease. Eur Arch Psychiatry Clin Neurosci 2013; 263(Suppl 2): S137\u2013S145.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz025"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251339840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251339840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251339840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:39Z","timestamp":1777371039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251339840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13872877251339840"],"URL":"https:\/\/doi.org\/10.1177\/13872877251339840","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]}}}