{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:20:36Z","timestamp":1790605236323,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depressive symptoms are common in Alzheimer's disease (AD), leading to an increasing use of antidepressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effects of vortioxetine with other conventional antidepressants on cognition in AD patients with depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis is a subgroup of a 12-month, prospective, randomized, open-label, parallel-group study involving 108 outpatients receiving either vortioxetine or escitalopram, paroxetine, or bupropion as part of routine care. Data were collected at baseline, 6 and 12 months. Cognitive symptoms were assessed using the Mini-Mental State Examination (MMSE), Attentive Matrices (AM), Coloured Progressive Matrices (CPR), and Digit Span; depressive symptoms using the Hamilton Depression Scale (HAM-D) and the Cornell Scale for Depression in Dementia (CSDD). Results for patients on vortioxetine were compared to those on other antidepressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total scores on cognitive measures improved in all groups. Improvements versus baseline in MMSE, AM, and CPM were statistically significant in the vortioxetine group (p\u2009&lt;\u20090.001), but not in the other antidepressant groups. Digit Span scores did not differ significantly from baseline. The between-group differences in MMSE, AM, and CPM changes were statistically significant in favor of vortioxetine (p\u2009&lt;\u20090.05), while the Digit Span change showed a trend towards superiority with vortioxetine, but did not reach statistical significance. The between-group differences in HAM-D and CSDD changes were also statistically significant for vortioxetine (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vortioxetine was superior in improving both cognitive and depressive symptoms compared to other antidepressants. Larger studies which may also help to understand whether the beneficial effect observed with vortioxetine was a direct effect or mediated by its specific antidepressant efficacy are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251340084","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T02:49:27Z","timestamp":1746672567000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Differential effects of antidepressants on cognition in Alzheimer's disease with depression: A sub-group analysis of an open-label, observational study"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3886-0965","authenticated-orcid":false,"given":"Eduardo","family":"Cumbo","sequence":"first","affiliation":[{"name":"Neurodegenerative Disorders Unit, ASP Caltanissetta, Caltanissetta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6051-0657","authenticated-orcid":false,"given":"Daniela","family":"Migliore","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disorders Unit, ASP Caltanissetta, Caltanissetta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00034"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2086"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.21r14328"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4450"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13807"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107411108"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040404"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.900"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070889"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.7.737"},{"key":"e_1_3_4_12_2","article-title":"Antidepressants for treating depression in dementia","volume":"8","author":"Dudas R","year":"2018","unstructured":"Dudas R, Malouf R, McCleery J, et al. 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