{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:29:08Z","timestamp":1777397348137,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korean Neuropsychiatric Research Foundation","award":["2024 Haesong Geriatric Psychiatry Research Fund"],"award-info":[{"award-number":["2024 Haesong Geriatric Psychiatry Research Fund"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia is a major public health challenge, yet existing prediction models often overlook sleep-related symptoms, despite their known links to cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate a four-year Dementia Risk Score (DRS) incorporating self-reported sleep-related symptoms with demographic and clinical factors to predict all-cause dementia, including Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 3082 Korean adults aged 60\u201379 years were analyzed. Predictors were selected using LASSO regression and included in a multivariate logistic regression model. A point-based scoring system, the DRS, was constructed from the model coefficients. Internal validation was conducted using bootstrapping and a separate dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The DRS achieved robust predictive performance, with AUC values of 0.824 in the training set and 0.826 in the validation set. Key predictors included sleep disturbance, use of sleep medications, daytime dysfunction, leg discomfort, and urge to move legs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DRS provides a practical, scalable tool for predicting dementia risk, supporting community-based screening and early intervention. External validation is needed to confirm its broader applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251340094","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:13:38Z","timestamp":1746677618000},"page":"280-292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A sleep-based risk model for predicting dementia: Development and validation in a Korean cohort"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7511-5272","authenticated-orcid":false,"given":"Hyukjun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-4257","authenticated-orcid":false,"given":"Ji Won","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea"},{"name":"Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-0354","authenticated-orcid":false,"given":"Seung Wan","family":"Suh","sequence":"additional","affiliation":[{"name":"Seoul Heal Mental Health Clinic, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-1869","authenticated-orcid":false,"given":"Hee Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Chungnam National University Hospital, Daejeon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-3490","authenticated-orcid":false,"given":"Dae Jong","family":"Oh","sequence":"additional","affiliation":[{"name":"Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South \rKorea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-8524","authenticated-orcid":false,"given":"Eunji","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-3384","authenticated-orcid":false,"given":"Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-7306","authenticated-orcid":false,"given":"Bong Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-1974","authenticated-orcid":false,"given":"Dong Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-4637","authenticated-orcid":false,"given":"Jeong Lan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8147-5782","authenticated-orcid":false,"given":"Jin Hyeong","family":"Jhoo","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-5284","authenticated-orcid":false,"given":"Joon Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-3557","authenticated-orcid":false,"given":"Jung Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-0105","authenticated-orcid":false,"given":"Kyung Phil","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-4697","authenticated-orcid":false,"given":"Seok Bum","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-8122","authenticated-orcid":false,"given":"Seok Woo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-8723","authenticated-orcid":false,"given":"Seung-Ho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-655X","authenticated-orcid":false,"given":"Shin Gyeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1103-3858","authenticated-orcid":false,"given":"Ki Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea"},{"name":"Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea"},{"name":"Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea"},{"name":"Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_3_3_2","volume-title":"Dementia: a public health priority","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. Dementia: a public health priority. Geneva, Switzerland: World Health Organization, 2012."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw032"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002331"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01191-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321896"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003732"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25166"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30450-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5768"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3832"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.025"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70537-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000447448"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086141"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0549-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2018.06.02"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-010-0052-7"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2022.02.007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.728"},{"key":"e_1_3_3_22_2","first-page":"1","article-title":"NIH state-of-the-science conference statement: preventing Alzheimer\u2019s disease and cognitive decline","volume":"27","author":"Daviglus ML","year":"2010","unstructured":"Daviglus ML, Bell CC, Berrettini W, et al. NIH state-of-the-science conference statement: preventing Alzheimer\u2019s disease and cognitive decline. NIH Consens State Sci Statements 2010; 27: 1\u201330.","journal-title":"NIH Consens State Sci Statements"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0697"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0579-9"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21740"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6840"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816d83e4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-018-1748-x"},{"key":"e_1_3_3_30_2","first-page":"768","article-title":"Usefulness of Berlin and STOP questionnaires as a screening test for sleep apnea in Korea","volume":"53","author":"Chul K","year":"2010","unstructured":"Chul K, Joong-Saeng C, Sung-Wan K. Usefulness of Berlin and STOP questionnaires as a screening test for sleep apnea in Korea. Korean J Otolaryngol Head Neck Surg 2010; 53: 768\u2013772.","journal-title":"Korean J Otolaryngol Head Neck Surg"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.10.007"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000496839"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23430"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2008.5.4.232"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90005-N"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/57.1.P47"},{"key":"e_1_3_3_38_2","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan DV","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22\u201333; quiz 34\u201357.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610214001379"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181cab764"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101094"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2014.11.1.39"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1159\/000297523"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"e_1_3_3_46_2","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association, 1994."},{"key":"e_1_3_3_47_2","article-title":"How to develop a more accurate risk prediction model when there are few events","volume":"351","author":"Pavlou M","year":"2015","unstructured":"Pavlou M, Ambler G, Seaman SR, et al. How to develop a more accurate risk prediction model when there are few events. Br Med J 2015; 351: h3868.","journal-title":"Br Med J"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.54117\/iimj.v3i1.5"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c30fb2"},{"key":"e_1_3_3_51_2","volume-title":"R: A language and environment for statistical computing","author":"Team RC","year":"2016","unstructured":"Team RC. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2016, http:\/\/www.R-project.org\/."},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108126"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1168\/2\/022022"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v13.i5.373"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.04.013"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(91)90005-W"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.34.4.553"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(75)90037-7"},{"key":"e_1_3_3_59_2","volume-title":"Growing older in America: The Health & Retirement Study","author":"Karp F","year":"2007","unstructured":"Karp F. Growing older in America: The Health & Retirement Study. Bethesda, MD: National Institute on Aging, National Institutes of Health, US Department of Health and Human Services, 2007."},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51054.x"},{"key":"e_1_3_3_61_2","first-page":"48","article-title":"Prevalence of sleep problems and quality of life in an older population","volume":"25","author":"Schubert CR","year":"2002","unstructured":"Schubert CR, Cruickshanks KJ, Dalton DS, et al. Prevalence of sleep problems and quality of life in an older population. Sleep 2002; 25: 48\u201352.","journal-title":"Sleep"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9154-6"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.05.012"},{"key":"e_1_3_3_64_2","article-title":"Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study","volume":"7","author":"Chen P-L","year":"2012","unstructured":"Chen P-L, Lee W-J, Sun W-Z, et al. Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study. PLoS One 2012; 7: e49113.","journal-title":"PLoS One"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1159\/000431311"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822c9148"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7676"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251340094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251340094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251340094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:40Z","timestamp":1777371040000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251340094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13872877251340094"],"URL":"https:\/\/doi.org\/10.1177\/13872877251340094","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}