{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:16:08Z","timestamp":1790273768184,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG051615"],"award-info":[{"award-number":["RF1 AG051615"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL169332"],"award-info":[{"award-number":["R01 HL169332"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG074971"],"award-info":[{"award-number":["R01 AG074971"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is driven by amyloid-\u03b2 (A\u03b2) plaque accumulation, but the mechanisms behind this process remain unclear. Omega-3 fatty acids, particularly docosahexaenoic acid (DHA), may offer protective effects, though their relationship with A\u03b2 accumulation is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated whether serum DHA and eicosapentaenoic acid (EPA) levels, measured 6\u20139 years before imaging, were inversely associated with cerebral A\u03b2 deposition in cognitively normal older adults in Japan, a population known for high omega-3 intake. We focused on individuals identified as A\u03b2-positive based on positron emission tomography (PET) scans, as they are at higher risk for AD progression, to assess DHA's potential in mitigating early amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An analytical sample of 97 older adults (75\u201389 years) from the Suita Study was analyzed. Serum DHA and EPA levels were assessed between 2008 and 2012, and amyloid PET was performed between 2016 and 2019. Multiple regression analyses were conducted, adjusting for age, sex,\n                      <jats:italic>APOE4<\/jats:italic>\n                      status, and cardiometabolic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 97 participants (49% males, 8.2%\n                      <jats:italic>APOE4<\/jats:italic>\n                      carriers), 37.1% (n\u2009=\u200936) had cardiometabolic disease, and 29.8% (n\u2009=\u200929) were A\u03b2 positive. In A\u03b2-positive individuals, higher serum DHA levels were significantly associated with lower A\u03b2 deposition independent of age, sex and\n                      <jats:italic>APOE4<\/jats:italic>\n                      status (standardized \u03b2\u2009=\u2009-0.423, p\u2009=\u20090.030). This became non-significant after additionally adjusting for cardiometabolic disease (\u03b2\u2009=\u2009-0.382, p\u2009=\u20090.059). No significant association was found between EPA and A\u03b2 deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher long-term DHA levels may help reduce A\u03b2 accumulation in those at risk for AD, supporting its potential role in early prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251340688","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:04:14Z","timestamp":1746673454000},"page":"378-386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["An inverse association of cerebral amyloid-\u03b2 deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-6321","authenticated-orcid":false,"given":"Akira","family":"Sekikawa","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-5989","authenticated-orcid":false,"given":"Aya","family":"Higashiyama","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan"},{"name":"Department of Hygiene, Wakayama Medical University, Wakayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-0203","authenticated-orcid":false,"given":"Brian J","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, 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