{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:58Z","timestamp":1787019178012,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Alzheimer's disease is characterized by declining memory and the presence of insoluble amyloid-\u03b2 (A\u03b2) plaques and neurofibrillary tangles in the brain. Gui et al.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">1<\/jats:xref>\n                    <\/jats:sup>\n                    studied the effects of low levels of\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    -lipopolysaccharide (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    -LPS) and soluble A\u03b2 on synaptic proteins, synapsin1 (SYN1) and post-synaptic density protein-95 (PSD-95). Their study revealed increased proinflammatory cytokine production in microglial cells (MG6) treated with\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    -LPS and A\u03b2, while neuronal cells, N2a, exposed to MG6-conditioned medium showed SYN1 and PSD-95 loss. This suggests that excessive neuroinflammation may contribute to synaptic protein and memory loss, offering mechanistic insights into\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    -LPS-mediated inflammatory pathways in periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/13872877251343317","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:12:42Z","timestamp":1747825962000},"page":"537-539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Porphyromonas gingivalis<\/i>\n                    -lipopolysaccharide and amyloid-\u03b2: A dangerous liaison for impairing memory?"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2949-2437","authenticated-orcid":false,"given":"Sim K","family":"Singhrao","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry, University of Central Lancashire, Preston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251326879"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1213448"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1477-1482.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5041-5051.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2018.1440128"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21655"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.04.013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.256pe6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.7.1635"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12010"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058496"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00747.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.12.002"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251343317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251343317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251343317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:43Z","timestamp":1777371043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251343317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13872877251343317"],"URL":"https:\/\/doi.org\/10.1177\/13872877251343317","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}