{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:18:15Z","timestamp":1778059095194,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25 NS080687"],"award-info":[{"award-number":["R25 NS080687"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23 AG061276"],"award-info":[{"award-number":["K23 AG061276"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054671"],"award-info":[{"award-number":["R01 AG054671"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG077627"],"award-info":[{"award-number":["RF1 AG077627"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MGH Executive Committee on Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High cardiorespiratory fitness has been associated with greater neuroplasticity, and slower neurodegeneration and cognitive decline in healthy adults. Yet, less is known about whether low-to-intermediate cardiorespiratory fitness is associated with lower markers of disease progression in the preclinical stage of Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated whether cardiorespiratory fitness was associated with plasma biomarkers for AD-related pathology, neural injury and astrocyte reactivity, and episodic memory in Presenilin-1 E280A carriers without dementia from the world's largest kindred with autosomal-dominant AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-seven mutation carriers (25 cognitively unimpaired, 2 with mild cognitive impairment; ages: \u03bc=30.22 years, SD\u2009=\u20095.24; 74% female) participated in the study. Participants underwent a graded aerobic fitness test to assess cardiorespiratory fitness, measured in maximum metabolic equivalent of task (MET). Plasma biomarkers included amyloid 42\/40, phosphorylated tau-181, neurofilament light chain, and glial fibrillary acidic protein. Participants completed the Consortium to Establish a Registry for AD word list learning and delayed recall. We conducted multiple linear regressions controlling for age, sex, and years of education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen participants\u2019 MET values were indicative of low cardiorespiratory fitness (&lt;\n                      <jats:underline>9<\/jats:underline>\n                      MET), and 13 participants\u2019 MET values of intermediate cardiorespiratory fitness (9\u201314 MET). METs were not associated with age, biomarkers, or episodic memory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that low-to-intermediate cardiorespiratory fitness may not be associated with biomarkers for AD-related pathology, neural injury and astrocyte reactivity, or memory in people at genetic risk for dementia. Longitudinal studies and randomized-controlled trials are needed to better understand the relationships among cardiorespiratory fitness and AD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251344327","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:24:32Z","timestamp":1748316272000},"page":"678-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association among cardiorespiratory fitness, plasma biomarkers of pathology and astrocyte reactivity, and cognition in autosomal-dominant Alzheimer's disease"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-0727","authenticated-orcid":false,"given":"Edmarie","family":"Guzm\u00e1n-V\u00e9lez","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Aguill\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9039-8887","authenticated-orcid":false,"given":"Angelys","family":"Rivera-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Puerto Rico-R\u00edo Piedras, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Y","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Londo\u00f1o-Sotomayor","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Picard","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur F","family":"Kramer","sequence":"additional","affiliation":[{"name":"Center for Cognitive and Brain Health, Northeastern University, Boston, MA, USA"},{"name":"Beckman Institute, University of Illinois, Urbana, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo I","family":"Caraballo-Gracia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Andrew","family":"Taylor","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9714-8244","authenticated-orcid":false,"given":"Yakeel T","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100657"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118196"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3059"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20398"},{"key":"e_1_3_4_10_2","first-page":"32","article-title":"Plasticity of brain networks in a randomized intervention trial of exercise training in older adults","volume":"2","author":"Voss MW","year":"2010","unstructured":"Voss MW, Prakash RS, Erickson KI, et al. 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