{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:46:14Z","timestamp":1784630774440,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Intervention of elderly dementia patients using comprehensive elderly assessment and observation of serum S100 \u03b2 The influence of proteins","award":["LKM2022072"],"award-info":[{"award-number":["LKM2022072"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that significantly impairs cognitive function, emotional health, and daily living activities. Comprehensive Geriatric Assessment (CGA) is a multidisciplinary approach designed to optimize health outcomes in older adults, but its effectiveness in managing AD remains to be fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of CGA intervention on serum S100\u03b2 levels and clinical outcomes in patients with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 120 patients diagnosed with AD were randomly assigned to either a Control group or an Intervention group. The Control group received standard treatment and routine care, while the Intervention group received individualized care plans based on CGA in addition to standard management. Primary outcomes included serum S100\u03b2 levels, Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS-Cog), Neuropsychiatric Inventory\u2013Questionnaire (NPI-Q), Geriatric Depression Scale (GDS) scores, Mini-Nutritional Assessment (MNA) scores, Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), and Parkinson's Disease Questionnaire (PDQ-39) scores, assessed at baseline and during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum S100\u03b2 levels remained stable in the Control group but significantly decreased in the Intervention group at 6 months. ADLs and IADLs scores were consistently higher in the Intervention group. Although ADAS-Cog and NPI-Q scores improved in both groups, the Intervention group demonstrated significantly lower NPI-Q scores at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CGA intervention effectively enhances cognitive function, emotional well-being, mobility, and social interaction in patients with AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251344544","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:56:38Z","timestamp":1750820198000},"page":"686-694","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of comprehensive geriatric assessment intervention on serum S100\u03b2 levels and clinical outcomes in patients with Alzheimer's disease"],"prefix":"10.1177","volume":"106","author":[{"given":"Da-wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ting","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8284-7594","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lianshui County People's Hospital, Huaian, Jiangu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-14207"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.09.018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.984046"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.15"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104831"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2023.03.018"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07559-5"},{"key":"e_1_3_3_13_2","article-title":"Post-acute care for frail older people decreases 90-day emergency room visits, readmissions and mortality: an interventional study","volume":"18","author":"Lee MC","year":"2023","unstructured":"Lee MC, Wu TY, Huang SJ, et al. 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