{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:17:00Z","timestamp":1779333420372,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Researchers have reported that hyperphosphorylated tau (p-tau) accumulates in the Cornu Ammonis 2 subfield (CA2) of the hippocampus with age, preferentially in primary age-related tau astrogliopathy, in association with early Alzheimer's disease, and preferentially in chronic traumatic encephalopathy neuropathologic change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Examine the possible association between preferential p-tau in the CA2 region of the hippocampus and history of playing high school American-style football.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Postmortem brain tissue samples were obtained from the Lieber Institute for Brain Development for 174 men (median age at death\u2009=\u200965 years; range\u2009=\u200950\u201396). There were 126 with no known history of participation in contact or collision sports and 48 (27.6%) who participated in football.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Approximately half were rated modified Braak stage I (47.1%) and modified CERAD stage 0 (52.0%). Preferential CA2 p-tau was present in 29.9%. The average age for those with versus without preferential CA2 p-tau was 75 and 63, respectively (Cohen's d\u2009=\u2009\u22121.27, large effect).<\/jats:p>\n                    <jats:p>The sport history groups did not differ in age (p\u2009=\u20090.607). In both univariate and multivariate logistic regressions, older age groups (odds ratio [OR]\u2009=\u20093.42 and 3.23) and those with greater modified CERAD scores (OR\u2009=\u20091.78 and 1.48) were significantly more likely to have preferential CA2 p-tau. There was not a significant association between football participation and preferential CA2 p-tau.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was not a significant association between participation in high school football and preferential CA2 p-tau identified after death. These results support other theories in the literature\u2014that preferential CA2 p-tau is associated with aging and with Alzheimer's disease neuropathologic change.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251351524","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:44:45Z","timestamp":1750913085000},"page":"1108-1119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football"],"prefix":"10.1177","volume":"106","author":[{"given":"Grant L","family":"Iverson","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation, Charlestown, \rMA, USA"},{"name":"Mass General for Children Sports Concussion Program, Boston, MA, USA"},{"name":"Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouya","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Deep-Soboslay","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M","family":"Hyde","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA"},{"name":"Department of Psychiatry &amp; 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