{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:02:33Z","timestamp":1794441753251,"version":"4.9.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Herpes zoster (HZ) infection may increase the risk of dementia, that causes a heavy socioeconomic burden. However, the epidemiological evidence between HZ vaccination and the risk of dementia remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis was conducted to investigate the effect of HZ vaccination on the onset of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, EMBASE, Web of Science, Science Direct, and Scopus for cohort studies assessing the association between HZ vaccination and dementia risk up to 20th January 2025. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled adopting a random-effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four eligible studies were included in the systematic review and five retrospective cohort studies in the meta-analysis. Among 14,493,383 dementia-free participants at baseline, 427,309 dementia cases occurred during 36\u201395 months of follow-up. All studies were of high quality. Pooled analysis of adjusted HRs indicated that HZ vaccination could reduce dementia risk by 29% (HR\u2009=\u20090.71, 95% CI: 0.66\u20130.76, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200997.15%). Subgroup analyses revealed heterogeneity linked to definitions of dementia, exposure measurements, vaccination doses, deprivation index, and region. The results were stable in the sensitivity analyses, and no publication bias was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HZ vaccination was notably related to a reduced risk of dementia. More mechanistic studies and epidemiological studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251351593","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:29:43Z","timestamp":1750732183000},"page":"1232-1241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between herpes zoster vaccination and the decreased risk of dementia: A systematic review and meta-analysis of cohort studies"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4835-5267","authenticated-orcid":false,"given":"Yishu","family":"Yin","sequence":"first","affiliation":[{"name":"Peking University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Peking University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University"},{"name":"Peking University"},{"name":"Peking University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"issue":"8","key":"e_1_3_3_4_2","article-title":"The burden of dementia","volume":"13","author":"Cotter VT","year":"2007","unstructured":"Cotter VT. The burden of dementia. Am J Manag Care 2007; 13(Suppl 8): S193\u2013S197.","journal-title":"Am J Manag Care"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683408"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-020-01157-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01418-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m11312"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.01.022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-018-0956-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00757-0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501184"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603800"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08800-x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12622"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045871"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221036"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16768-4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257405"},{"key":"e_1_3_3_22_2","article-title":"Reduced dementia incidence after varicella zoster vaccination in Wales 2013\u20132020","volume":"8","author":"Schnier C","year":"2022","unstructured":"Schnier C, Janbek J, Lathe R, et al. Reduced dementia incidence after varicella zoster vaccination in Wales 2013\u20132020. Alzheimers Dement (N Y) 2022; 8: e12293.","journal-title":"Alzheimers Dement (N Y)"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126673"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3415"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.872542"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12060566"},{"key":"e_1_3_3_27_2","first-page":"97","article-title":"Vaccination reduces risk of Alzheimer's disease, Parkinson's disease and other neurodegenerative disorders","volume":"34","author":"Lehrer S","year":"2022","unstructured":"Lehrer S, Rheinstein PH. Vaccination reduces risk of Alzheimer's disease, Parkinson's disease and other neurodegenerative disorders. 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