{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:54Z","timestamp":1791959874645,"version":"4.3.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Genetic frontotemporal dementia (FTD) along with Alzheimer's disease (AD), is one of the most prevalent early-onset dementias. The differential diagnosis of FTD from primary psychiatric disorder (PPD) has been challenging due to significant symptom overlap, particular as FTD often presents with prolonged psychiatric prodromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate whether blood-based neurofilament light chain (NfL) can differentiate genetic FTD from PPD, and to determine a global clinical cutoff to differentiate genetic FTD carriers from PPD with high specificity and sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data (ages 40\u201381) were obtained from FTD mutation carriers (GENFI;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009474;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009120\n                      <jats:italic toggle=\"yes\">C9orf72, n<\/jats:italic>\n                      \u2009\n                      <jats:italic toggle=\"yes\">=<\/jats:italic>\n                      \u2009114\n                      <jats:italic toggle=\"yes\">GRN, n<\/jats:italic>\n                      \u2009=\u200950\n                      <jats:italic toggle=\"yes\">MAPT<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009190 controls), and PPD (Biobanque Signature;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009848). Blood-based NfL was measured with SIMOA HD-X (BbS) and SIMOA HD-1 (GENFI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blood-based NfL was higher in all symptomatic mutations compared to PPD. Mildly symptomatic (0\u2009&lt;\u2009FTLD CDR-SOB-NM\u2009&lt;\u20094)\n                      <jats:italic toggle=\"yes\">C9orf72<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">GRN<\/jats:italic>\n                      carriers also had higher NfL. ROC curve revealed an optimal blood-based NfL cutoff of 22.1\u2005pg\/mL (\n                      <jats:italic toggle=\"yes\">J<\/jats:italic>\n                      \u2009=\u20090.647) to distinguish symptomatic genetic FTD from PPD (78.5% sensitivity, 86.2% specificity, AUC\u2009=\u20090.908). For mildly symptomatic subjects, a cutoff of 16.2\u2005pg\/mL (\n                      <jats:italic toggle=\"yes\">J<\/jats:italic>\n                      \u2009=\u20090.601) differentiated groups with 86.7% sensitivity and 73.5% specificity (AUC\u2009=\u20090.870).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      NfL holds potential as a blood-based biomarker for symptomatic genetic FTD carriers, with moderate accuracy to distinguish PPD from mild forms including\n                      <jats:italic toggle=\"yes\">C9orf72<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251352103","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T02:54:48Z","timestamp":1751511288000},"page":"1337-1354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1854-9835","authenticated-orcid":false,"given":"Ella","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-7198","authenticated-orcid":false,"given":"Sherri Lee","family":"Jones","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0621-7970","authenticated-orcid":false,"given":"Victoria","family":"Light","sequence":"additional","affiliation":[{"name":"Amsterdam Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, North Holland, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Amsterdam Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, North Holland, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-5893","authenticated-orcid":false,"given":"Lucy L","family":"Russell","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-6598","authenticated-orcid":false,"given":"Phoebe H","family":"Foster","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5083-0901","authenticated-orcid":false,"given":"Eve","family":"Ferry-Bolder","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre, Rotterdam, South Holland, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lize C","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre, Rotterdam, South Holland, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-7527","authenticated-orcid":false,"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre, Rotterdam, South Holland, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-490X","authenticated-orcid":false,"given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire, D\u00e9partement des Sciences Neurologiques, CHU de Qu\u00e9bec, and Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-2951","authenticated-orcid":false,"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet, Huddinge, S\u00f6dermanland, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-5953","authenticated-orcid":false,"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico, Milano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Campus O&amp;N II, Leuven, Flemish Brabant, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-1453","authenticated-orcid":false,"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-9434","authenticated-orcid":false,"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"University Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Beira Litoral, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-6062","authenticated-orcid":false,"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Withington, Manchester, Greater Manchester, UK"},{"name":"Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, North Rhine-Westphalia, Germany"},{"name":"Department of Geriatric Medicine, Klinikum Hochsauerland, Arnsberg, North Rhine-Westphalia, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital, LMU Munich, M\u00fcnchen, Bavaria, Germany"},{"name":"Germany Center for Neurodegenerative Diseases, site Munich, M\u00fcnchen, Bavaria, Germany"},{"name":"Department of Neurology, Munich Cluster for Systems Neurology (SyNergy), M\u00fcnchen, Bavaria, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Neurofarba, University of Florence, Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Baden-W\u00fcrttemberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris R","family":"Butler","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, Oxfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-5181","authenticated-orcid":false,"given":"Isabelle Le","family":"Ber","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute \u2013 Institut du Cerveau \u2013 ICM, H\u00f4pital Piti\u00e9, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, London Health Sciences Centre, University Hospital, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8497","authenticated-orcid":false,"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust, and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of T\u00fcbingen, T\u00fcbingen, Baden-W\u00fcrttemberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5200-3164","authenticated-orcid":false,"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit, Department of Neurology, Donostia Universitary Hospital, Donostia-San Sebasti\u00e0n, Gipuzkoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9814","authenticated-orcid":false,"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, Greater London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-1113","authenticated-orcid":false,"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Qu\u00e9bec, Canada"},{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Genetic Frontotemporal Dementia Initiative (GENFI) and Banque Signature (BbS)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.117"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14101248"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2023.08.017"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.18050114"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.015"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8110523"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51524"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14612-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.03.019"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51234"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa018"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09567-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.679199"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2024.03.008"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-326914"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100607"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01942-9"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70324-2"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330152"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11442-y"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30394-1"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2017.1286324"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2016.08.042"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321954"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2023.22.3.109"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.045278"},{"key":"e_1_3_4_30_2","volume-title":". Statistics in medicine","author":"Riffenburgh RH","year":"2006","unstructured":"Riffenburgh RH. Chapter 11 - Using the reference guide. Statistics in medicine. 2nd ed. London: Academic Press Elsevier, 2006.","edition":"2"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0439-y"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24954"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.776523"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06185-7"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000173837.82820.9f"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12979"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-016-0007-6"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.325"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30354-0"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26265"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011848"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.088"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12675"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227047f"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae230"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2023-332464"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02524-6"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251352103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251352103","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251352103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:41:06Z","timestamp":1785742866000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251352103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/13872877251352103"],"URL":"https:\/\/doi.org\/10.1177\/13872877251352103","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}