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Depressive symptoms were assessed using the Geriatric Depression Scale (GDS). Cross-sectional linear regression models examined interactions between age and GDS scores, adjusting for sex, apolipoprotein \u03b54 (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54) carriage, and age difference between PET imaging and GDS assessment. GDS-stratified analyses were performed to test within-group associations between age and\n                      <jats:sup>11<\/jats:sup>\n                      C-PiB-PET A\u03b2 aggregation in each ROI, and item-level analyses identified specific depressive symptoms that modified these relationships.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants had a mean age of 68.0 years (SD\u2009\u00b1\u20098.4), 39.7% were\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers, 64% were female, and 85.3% were White. GDS scores were largely normal (M\u2009=\u20091.29, SD\u2009=\u20091.61). Age\u2009\u00d7\u2009GDS interactions were significant across all ROIs, and stratified models revealed progressively stronger associations as GDS scores increased. Finally, item-level analyses identified the second and tenth GDS items as significant modifiers across six ROIs and the global composite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a cohort enriched with risk for AD, emerging depressive symptoms amplified the association between age and A\u03b2 burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251353098","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:51:31Z","timestamp":1752137491000},"page":"1252-1260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Depression modifies age-associated [\n                    <sup>11<\/sup>\n                    C]PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer's disease"],"prefix":"10.1177","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-4116","authenticated-orcid":false,"given":"Kyle J","family":"Edmunds","sequence":"first","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Institute of Biomedical and Neural Engineering (IBNE), Reykjav\u00edk University, Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5414-2913","authenticated-orcid":false,"given":"Alexis R","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia L","family":"Brach","sequence":"additional","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9152-4637","authenticated-orcid":false,"given":"Matthew","family":"Glittenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-1352","authenticated-orcid":false,"given":"Tobey J","family":"Betthauser","sequence":"additional","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Geriatric Research Education and Clinical Center, William S. 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