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Amyloid-\u03b2 protein precursor (A\u03b2PP) plays a central role in AD pathology, as it is cleaved by \u03b2-secretase and \u03b3-secretase enzymes to generate A\u03b2 peptides and oligomers which aggregate to form neurotoxic fibrils and plaques in the brain. Increased A\u03b2PP expression has been correlated to A\u03b2 suggesting a larger role for A\u03b2PP function potentially through A\u03b2PP isoforms. Alternative splicing (AS) of APP pre-mRNA has emerged as a key regulatory mechanism influencing A\u03b2PP function through the generation of distinct isoforms. Similarly, the microtubule-associated protein tau (MAPT) is also subject to alternative splicing, producing isoforms that can contribute to hyperphosphorylation and neurodegeneration. In this review, we explore the role of APP alternative splicing and the regulation of its isoform expression in AD and other neurodegenerative disorders, with a focus on its potential impact on A\u03b2 peptide production. We also discuss recent advances in therapies targeting dysregulated splicing in neurodegenerative diseases and their potential relevance to AD. 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